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Aβ peptides and the exposure of their hydrophobic residues upon copper(ii) complex formation: probing mechanisms of amyloid plaque formation in human and rat peptide complexes
(2015-04)
Alzheimer’s Disease (AD) is a progressive, neurodegenerative disease that affects 35 million people worldwide and is the 6th leading cause of death in the United States. AD is characterized by neurofibrillary tangles and ...
Installation of Metal-Binding Functionality at Lysine Residues via Azide-Alkyne "Click Chemistry"
(2015-04-29)
A novel non-natural amino acid designed to bind divalent metal ions, dubbed Lys(PYRIT), was prepared in a “click reaction” by treating Fmoc-Lys(N3)-OH with 2-ethynylpyridine and Cu(I). It was incorporated into a 12-residue ...
THE EFFECTS OF PRENATAL LEAD EXPOSURE ON THE DEVELOPMENT OF BIOMARKERS OF ALZHEIMER’S DISEASE
(2015-04)
While often well known for its adverse effects on memory, Alzheimer’s disease (AD) is also noteworthy for being the sixth leading cause of death in the United States. An estimated 5.2 million Americans had the disease as ...
Investigating the Relationship between Environmental Lead Exposures and the Onset of Alzheimer's Disease Pathologies
(2014)
It is been estimated that nearly 5 million Americans suffer from Alzheimer's Disease (AD), making finding its cause one of medicine's top priorities. It has long been known that genetics plays a major role in the development ...
AGE-DEPENDENT STUDY OF PATHOLOGICAL PROGRESSION OF ALZHEIMER’S DISEASE IN HIPPOCAMPAL AND CORTICAL TISSUE OF HUMAN AND AN AD MOUSE MODEL
(East Carolina University, 2019-05-02)
Degeneration of synaptic plasticity plays a critical role in Alzheimer’s disease (AD) pathogenesis. Recent studies have suggested that neuroinflammation may contribute to this degeneration by disrupting the amyloid metabolism ...