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Now showing items 497-516 of 2637
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The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through anti-proliferative and pro-apoptotic effects
(East Carolina University, 2009-06)Guanosine-specific cyclic nucleotide signaling is suggested to serve protective actions in the vasculature; however, the influence of selective pharmacologic modulation of cyclic guanosine monophosphate (GMP)-synthesizing ... -
The cyclic-di-GMP signaling pathway in the Lyme disease spirochete,
(2014-05)In nature, the Lyme disease spirochete Borrelia burgdorferi cycles between the unrelated environments of the Ixodes tick vector and mammalian host. In order to survive transmission between hosts, B. burgdorferi must be ... -
Cystic Fibrosis Virtual Patient Advocacy
(2021-07-27)Cystic Fibrosis is a rare life-limiting genetic disorder that affects 30,000 people in the United States. The CF population has seen an increase in their life expectancy as new research, therapies and technology has ... -
CYTOKINE-BASED FUSION PROTEINS FOR TREATMENT OF MULTIPLE SCLEROSIS
(2014-12-30)The present invention provides fusion proteins including an autoimmune antigen, an allergen antigen or an alloantigen, and an anti-inflammatory cytokine. Compositions and meth ods including the fusion proteins are also provided. -
Cytokine-Neuroantigen Fusion Proteins as a New Class of Tolerogenic, Therapeutic Vaccines for Treatment of Inflammatory Demyelinating Disease in Rodent Models of Multiple Sclerosis
(2012-08)Myelin-specific induction of tolerance represents a promising means to modify the course of autoimmune inflammatory demyelinating diseases such as multiple sclerosis (MS). Our laboratory has focused on a novel preclinical ... -
Cytokines and neuroantigens for treatment of immune disorders
(2017-05-10)The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. ... -
Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
(2015-01)Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited colony ... -
Daily walks can improve digestion, chronic conditions
(2023-09-13)This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column is "Daily walks can improve digestion, chronic conditions." -
Dare County Quality Improvement Project for the Overweight and Obese Adult Patient
(2019-04-15)Obesity is a serious disease that has tripled in prevalence since the 1980s, it affects all Americans either directly or indirectly, and attributes to several serious comorbidities and premature death. While guidelines do ... -
DASH Diet Education for Improvement in Hypertensive Outcomes
(2020-04-30)Hypertension is a leading risk factor for cardiovascular disease (AHA, 2015). Although hypertension is a modifiable risk factor, 54% of an estimated one million adults with hypertension have poorly controlled hypertension ... -
Data-Related Support in U.S.-Based Health Sciences Libraries: An Analysis of AAHSL Member Sites
(2020-10-20)Scientific research is increasingly data-intensive, bringing with it new challenges related to the collection, analysis, storage, preservation, accessibility and communication of data. Federal funders, seeking to increase ... -
Deciphering the impact of fructose metabolism on liver mitochondrial bioenergetics
(East Carolina University, 2021-12-07)Since its discovery in 1980, the interest in nonalcoholic fatty liver disease, the liver manifestation of metabolic syndrome, has expanded due to the growing impact on the world's health. Commonly characterized by ... -
Decreasing Door-to-triage Times in the Emergency Department
(2023-07-14)In the emergency department, patients who are waiting for triage present with potentially time-sensitive and life-threatening conditions. The period of time between arrival and triage is rarely discussed in the literature, ...