Browsing Health Sciences Campus by Author "Malur, Anagha"
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Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes
Dalrymple, Heidi; Barna, Barbara P.; Malur, Anagha; Malur, Achut G.; Kavuru, Mani S.; Thomassen, Mary Jane (2013)Background Activin A is a pleiotrophic regulatory cytokine, the ablation of which is neonatal lethal. Healthy human alveolar macrophages (AMs) constitutively express activin A, but AMs of patients with pulmonary alveolar ... -
Carbon Nanotube-Induced Pulmonary Granulomatous Disease: 1 and Alveolar Macrophage M1 Activation
Barna, Barbara P.; Huizar, Isham; Malur, Anagha; McPeek, Matthew; Marshall, Irene; Jacob, Mark; Dobbs, Larry; Kavuru, Mani S.; Thomassen, Mary Jane (2013-12)Sarcoidosis, a chronic granulomatous disease of unknown cause, has been linked to several environmental risk factors, among which are some that may favor carbon nanotube formation. Using gene array data, we initially ... -
Elevated MicroRNA-33 in Sarcoidosis and a Carbon Nanotube Model of Chronic Granulomatous Disease
Bowling, Mark R.; Barna, Barbara P.; McPeek, Matthew; Malur, Anagha; Wingard, Christopher J.; Dobbs, Larry; Verbanac, Kathryn M.; Thomassen, Mary Jane (2016-06-01) -
The M2a Macrophage Phenotype Accompanies Pulmonary Granuloma Resolution in Mmp12 Knock-Out Mice Instilled with Multiwall Carbon Nanotubes
Ogburn, David; Bhalla, Sophia; Leffler, Nan; Mohan, Arjun; Malur, Anagha; Malur, Achut G.; McPeek, Matthew; Barna, Barbara P.; Thomassen, Mary Jane (2021-10-13) -
Myeloid ABCG1 Deficiency Enhances Apoptosis and Initiates Efferocytosis in Bronchoalveolar Lavage Cells of Murine Multi-Walled Carbon Nanotube-Induced Granuloma Model
Soliman, Eman; Bhalla, Sophia; Malur, Anagha; Ogburn, David; Leffler, Nancy; Thomassen, Mary Jane; Elhassanny, Ahmed E. M.; Malu, Achut G. (2022) -
Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis
Malur, Anagha; Kavuru, Mani S.; Marshall, Irene; Barna, Barbara P.; Huizar, Isham; Karnekar, Reema; Thomassen, Mary Jane (2012)Rationale Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP ... -
The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
Huizar, Isham; Malur, Anagha; Patel, Janki; McPeek, Matthew; Dobbs, Larry; Wingard, Christopher J.; Barna, Barbara P.; Thomassen, Mary Jane (2013)BACKGROUND: Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products ... -
Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells
Gharib, Sina A.; Malur, Anagha; Huizar, Isham; Barna, Barbara P.; Kavuru, Mani S.; Schnapp, Lynn M.; Thomassen, Mary J. (2016-07-26)Abstract Background Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased ...