Browsing Brody School of Medicine by Title
Now showing items 97-116 of 884
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Ca2+ and Ionic Strength Dependencies of S1-ADP Binding to Actin-Tropomyosin-Troponin: Regulatory Implications
(East Carolina University, 2004-09)Skeletal and cardiac muscle contraction are inhibited by the actin-associated complex of tropomyosin-troponin. Binding of Ca21 to troponin or binding of ATP-free myosin to actin reverses this inhibition. Ca21 and ATP-free ... -
Calcium Dependent CAMTA1 in Adult Stem Cell Commitment to a Myocardial Lineage
(2012)The phenotype of somatic cells has recently been found to be reversible. Direct reprogramming of one cell type into another has been achieved with transduction and over expression of exogenous defined transcription factors ... -
Calponin interaction with alpha-actinin-actin: evidence for a structural role for calponin.
(East Carolina University, 1999-12)The purpose of this study was to address the paradox of calponin localization with a-actinin and filamin, two proteins with tandem calponin homology (CH) domains, by determining the effect of these proteins on the binding ... -
Cancer mortality in Native Americans in North Carolina.
(East Carolina University, 1990-08)his paper describes age-adjusted mortality from malignant neoplasms for Native Americans in North Carolina for 1968-72 and 1978-82. Sex-specific standardized mortality ratios were calculated from death certificate data, ... -
Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness
(2011)Background Previously we have found that cannabinoid treatment of zebra finches during sensorimotor stages of vocal development alters song patterns produced in adulthood. Such persistently altered behavior must be ... -
Cannabinoid receptor 1 signaling in cardiovascular regulating nuclei in the brainstem: A review
(2013-04)Cannabinoids elicit complex hemodynamic responses in experimental animals that involve both peripheral and central sites. Centrally administered cannabinoids have been shown to predominantly cause pressor response. However, ... -
Capture of heat-killed Mycobacterium bovis bacillus Calmette-Guérin by intelectin-1deposited on cell surfaces
(East Carolina University, 2009-05)Intelectin is an extracellular animal lectin found in chordata. Although human and mouse intelectin-1 recognize galactofuranosyl residues included in cell walls of various microorganisms, the physiological function of ... -
Carbon Nanotube-Induced Pulmonary Granulomatous Disease: 1 and Alveolar Macrophage M1 Activation
(2013-12)Sarcoidosis, a chronic granulomatous disease of unknown cause, has been linked to several environmental risk factors, among which are some that may favor carbon nanotube formation. Using gene array data, we initially ... -
Cardiac tamponade and pericardial disorders in connective tissue diseases: case report and literature review.
(East Carolina University, 1994-02)Pericardial disorders occurring in connective tissue diseases are not uncommon and may present as acute or chronic pericarditis with or without an effusion. In many instances, a diagnosis of pericardial involvement is not ... -
Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
(East Carolina University, 2016-05-03)Coronary heart disease is a leading cause of death in the United States, totaled mostly by deaths associated with myocardial infarction and fatal ventricular arrhythmias. The inability to predict the occurrence of these ... -
Cardiovascular effects in patrol officers are associated with fine particulate matter from brake wear and engine emissions
(East Carolina University, 2004-12-09)Background: Exposure to fine particulate matter air pollutants (PM2.5) affects heart rate variability parameters, and levels of serum proteins associated with inflammation, hemostasis and thrombosis. This study investigated ... -
Cardiovascular Outcomes Following Xenobiotic Pulmonary Exposures
(East Carolina University, 2017-07-06)Cardiovascular disease remains the leading cause of mortality in the developed world. Over the past decades, investigations have demonstrated that pulmonary exposure to xenobiotic particulate matter promotes and exacerbates ... -
A case control study of environmental and occupational exposures associated with methicillin resistant nasal carriage in patients admitted to a rural tertiary care hospital in a high density swine region
(2014)Background Distinct strains of methicillin resistant Staphylococcus aureus (MRSA) have been identified on livestock and livestock workers. Industrial food animal production may be an important environmental reservoir for ... -
A case of successfully treated with voriconazole
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Catabolite repression control (crc) gene and pseudomonas virulence
(2002-08-22)A method of screening for compounds that inhibit the virulence of Pseudomonas bacteria comprises the steps of: providing a culture medium comprising Pseudomonas bacteria; administering a test compound to said bacteria; and ... -
Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in
(2015)Catalpol is an effective component of rehmannia root and known to possess various pharmacological properties. The present study was aimed at investigating the potential effects of catalpol on the lifespan and stress tolerance ... -
Catecholamine metabolism via monoamine oxidase (MAO) within myocardium of individuals with type 2 diabetes
(East Carolina University, 2019-04-23)The primary comorbidity and cause of mortality in type 2 diabetes is cardiovascular disease. The structural and the functional cardiac remodeling observed in patients with type 2 diabetes has been shown to be driven by a ... -
CB1 Cannabinoid Receptor Activation Dose-Dependently Modulates Neuronal Activity within Caudal but not Rostral Song Control Regions of Adult Zebra Finch Telencephalon
(East Carolina University, 2008-08)CB1 cannabinoid receptors are distinctly expressed at high density within several regions of zebra finch telencephalon including those known to be involved in song learning (lMAN and Area X) and production (HVC and RA). ... -
CBD products require care
(2020-09-19)This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column defines CBD oils and hemp products. Discusses the risks and potential benefits of its use; the legal status in NC in 2020; ...