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Fesselin, an intrinsically disordered smooth muscle protein, organizes and stabilizes actin-myosin and myosin
(East Carolina University, 2014)
Fesselin is an intrinsically disordered protein that is known to bind a large variety of cytoskeletal proteins. The proteins fesselin is known to bind include: actin (Leinweber et al. 1999), [alpha]-actinin (Pham et al. ...
TMEFF2 is an epigenetic modulator that promotes androgen independent growth in castration-resistant prostate cancer cells
(East Carolina University, 2014)
While the ability to detect PCa has improved significantly due to PSA screenings, the survival rate for men diagnosed with PCa has remained stagnant, and the disease remains the second leading cause of cancer related deaths ...
Sugar-Sweetened Beverage Consumption and Food Insecurity in Pediatric Patients with Obesity
(2015-04-30)
Consumption of sugar sweetened beverages and food insecurity are both thought to contribute to the development of obesity. However, little is known about the quantity and quality of sugar-sweetened beverages consumed, the ...
The Need for Interprofessional Collaborative Ready Nutrition and Dietetics Practitioners
(2014-10-01)
This is the full length paper of what turned out to be a published brief after going through peer review. Many of our colleagues have requested the original full length description which is more of a call to action for ...
CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention
(East Carolina University, 2016-12-15)
Hyaluronan (HA) plays an essential role in cartilage where it functions to retain aggrecan. Previous studies suggested that aggrecan is anchored indirectly to the plasma membrane of chondrocytes via its binding to ...
A community-based lifestyle and weight loss intervention promoting a Mediterranean-style diet pattern evaluated in the stroke belt of North Carolina: the Heart Healthy Lenoir Project
(2016-08-05)
Abstract
Background
Because residents of the southeastern United States experience disproportionally high rates of cardiovascular disease (CVD), it is important to develop ...
Motility and chemotaxis in the Lyme disease spirochete Borrelia burgdorferi : role in pathogenesis
(East Carolina University, 2016-08-18)
Lyme disease is the most prevalent vector-borne disease in United States and is caused by the spirochete Borrelia burgdorferi. The disease is transmitted from an infected Ixodes scapularis tick to a mammalian host. B. ...
Maternal cadmium, iron and zinc levels, DNA methylation and birth weight
(2015-07)
Background
Cadmium (Cd) is a ubiquitous and environmentally persistent toxic metal that has been implicated in neurotoxicity, carcinogenesis and obesity and essential metals including zinc (Zn) and iron (Fe) may alter ...
Farmers’ market use is associated with fruit and vegetable consumption in diverse southern rural communities
(2014)
Background
While farmers’ markets are a potential strategy to increase access to fruits and vegetables in rural areas, more information is needed regarding use of farmers’ markets among rural residents. Thus, this study’s ...
Blocked Randomization with Randomly Selected Block Sizes
(2011-01)
When planning a randomized clinical trial, careful consideration must be given to how participants are selected for various arms of a study. Selection and accidental bias may occur when participants are not assigned to ...