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Th1 Adjuvant N-Acetyl-d-Glucosamine Polymer Up-Regulates Th1 Immunity but Down-Regulates Th2 Immunity against a Mycobacterial Protein (MPB-59) in Interleukin-10-Knockout and Wild-Type Mice
(East Carolina University, 2001-10)
Treatment of mice with heat-killed (HK) Mycobacterium bovis BCG or 1- to 10-μm chitin particles (nonantigenic N-acetyl-d-glucosamine polymers) is known to induce innate immune responses, including gamma interferon (IFN-γ) ...
Effect of gender on auditory brainstem response latencies and thresholds to air-and bone-conducted clicks in newborn infants
(East Carolina University, 2001)
Objective: An examination of gender differences in auditory brainstem response (ABR) wave V latencies and thresholds to air-and bone- conducted clicks was undertaken with newborn infants. Design: Two hundred and two full-term ...
Oral citrulline as arginine precursor may be beneficial in sickle cell disease: early phase two results.
(East Carolina University, 2001-10)
L-Arginine may be a conditionally essential amino acid in children and adolescents with sickle cell disease, particularly as required substrate in the arginine-nitric oxide pathway for endogenous nitrovasodilation and ...
Transcriptional Activation of Bordetella Alcaligin Siderophore Genes Requires the AlcR Regulator with Alcaligin as Inducer
(East Carolina University, 2001-01)
Genetic and biochemical studies have established that Fur and iron mediate repression of Bordetella alcaligin siderophore system (alc) genes under iron-replete nutritional growth conditions. In this study, transcriptional ...
Enhanced Avidity Maturation of Antibody to Human Immunodeficiency Virus Envelope: DNA Vaccination with gp120-C3d Fusion Proteins
(East Carolina University, 2001-06-10)
DNA vaccination can elicit both humoral and cellular immune responses and can confer protection against several pathogens. However, DNA vaccines expressing the envelope (Env) protein of human immunodeficiency virus (HIV) ...
Inhibition of Quorum Sensing by a Pseudomonas aeruginosa dksA Homologue
(East Carolina University, 2001-03)
The Pseudomonas aeruginosa las (lasR-lasI) and rhl (rhlR-rhlI) quorum-sensing systems regulate the expression of several virulence factors, including elastase and rhamnolipid. P. aeruginosa strain PR1-E4 is a lasR deletion ...
Robotic Surgical Training in an Academic Institution
(East Carolina University, 2001-10)
Objective
To detail robotic procedure development and clinical applications
for mitral valve, biliary, and gastric reflux operations, and
to implement a multispecialty robotic surgery training curriculum
for both ...
Multicenter Trial of Sentinel Node Biopsy for Breast Cancer Using Both Technetium Sulfur Colloid and Isosulfan Blue Dye
(East Carolina University, 2001-01)
Objective
To determine the factors associated with false-negative results
on sentinel node biopsy and sentinel node localization
(identification rate) in patients with breast cancer enrolled in a
multicenter ...
Evidence for the presence of A1 adenosine receptors in the aorta of spontaneously hypertensive rats
(East Carolina University, 2001-12)
1 Isolated aortic rings (endothelium-intact and -denuded) from spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats were used in this study to examine the vasoactive e ects of various adenosine analogues. 2 In ...
Fesselin, a Synaptopodin-like Protein, Stimulates Actin Nucleation and Polymerization
(East Carolina University, 2001-11-27)
Fesselin is a proline-rich actin binding protein that has recently been isolated from smooth muscle [Leinweber, B. D., Fredricksen, R. S., Hoffman, D. R., and Chalovich, J. M. (1999) J. Muscle Res. Cell Motil. 20, 539–545]. ...