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Functions of claudin-7 in human lung cancer
(East Carolina University, 2012)
Lung cancer is the second most common cancer and the most common cause of cancer-related death in both men and women in the United States with a very poor overall 5-year survival rate. Nearly 95% of the lung cancer originates ...
CD44 and hyaluronan promote the bmp7 signaling response in chondrocytes
(East Carolina University, 2011)
Cell-matrix interactions are important in maintaining cartilage homeostasis. Hyaluronan binding to its principal receptor CD44 is essential for such interactions. Hyaluronan-CD44 interactions are required for the retention ...
The intracellular proteolytic fragment of CD44 alters CD44 function in chondrocytes
(East Carolina University, 2010)
CD44 is an adhesion molecule involved in several biological functions and the primary receptor for hyaluronan (HA). In cartilage, CD44 participates in the interplay between cells and the extracellular matrix to fine tune ...
The extracellular processing of aggrecan aggregate and its effect on CD44 mediated internalization of hyaluronan.
(East Carolina University, 2015)
In many cells the hyaluronan receptor CD44 mediates the endocytosis of hyaluronan and its delivery to endosomes / lysosomes. The regulation of this process remains largely unknown. In most extracellular matrices hyaluronan ...
PPP1R42 is a positive regulator of PP1 in centrosome duplication and separation and cilia dynamics
(East Carolina University, 2014)
The centrosome is a dynamic structure that undergoes structural and functional transitions, which are coordinated with the cell cycle. It functions as the microtubule organizing center (MTOC) in interphase, duplicates and ...