Widespread brain reorganization perturbs visuomotor coordination in early glaucoma
Author
Trivedi, Vivek; Bang, Ji Won; Parra, Carlos; Colbert, Max K.; O’Connell, Caitlin; Arshad, Ahmel; Faiq, Muneeb A.; Conner, Ian P.; Redfern, Mark S.; Wollstein, Gadi; Schuman, Joel S.; Cham, Rakie; Chan, Kevin C.
Abstract
Glaucoma is the world’s leading cause of irreversible blindness, and falls are a major public health
concern in glaucoma patients. Although recent evidence suggests the involvements of the brain toward
advanced glaucoma stages, the early brain changes and their clinical and behavioral consequences
remain poorly described. This study aims to determine how glaucoma may impair the brain structurally
and functionally within and beyond the visual pathway in the early stages, and whether these changes
can explain visuomotor impairments in glaucoma. Using multi-parametric magnetic resonance
imaging, glaucoma patients presented compromised white matter integrity along the central visual
pathway and around the supramarginal gyrus, as well as reduced functional connectivity between the
supramarginal gyrus and the visual occipital and superior sensorimotor areas when compared to healthy
controls. Furthermore, decreased functional connectivity between the supramarginal gyrus and the
visual brain network may negatively impact postural control measured with dynamic posturography
in glaucoma patients. Taken together, this study demonstrates that widespread structural and
functional brain reorganization is taking place in areas associated with visuomotor coordination in early
glaucoma. These results implicate an important central mechanism by which glaucoma patients may be
susceptible to visual impairments and increased risk of falls.
Date
2019-10-02
Citation:
APA:
Trivedi, Vivek, & Bang, Ji Won, & Parra, Carlos, & Colbert, Max K., & O’Connell, Caitlin, & Arshad, Ahmel, & Faiq, Muneeb A., & Conner, Ian P., & Redfern, Mark S., & Wollstein, Gadi, & Schuman, Joel S., & Cham, Rakie, & Chan, Kevin C.. (October 2019).
Widespread brain reorganization perturbs visuomotor coordination in early glaucoma.
,
(),
-
. Retrieved from
http://hdl.handle.net/10342/8367
MLA:
Trivedi, Vivek, and Bang, Ji Won, and Parra, Carlos, and Colbert, Max K., and O’Connell, Caitlin, and Arshad, Ahmel, and Faiq, Muneeb A., and Conner, Ian P., and Redfern, Mark S., and Wollstein, Gadi, and Schuman, Joel S., and Cham, Rakie, and Chan, Kevin C..
"Widespread brain reorganization perturbs visuomotor coordination in early glaucoma". .
. (),
October 2019.
May 21, 2024.
http://hdl.handle.net/10342/8367.
Chicago:
Trivedi, Vivek and Bang, Ji Won and Parra, Carlos and Colbert, Max K. and O’Connell, Caitlin and Arshad, Ahmel and Faiq, Muneeb A. and Conner, Ian P. and Redfern, Mark S. and Wollstein, Gadi and Schuman, Joel S. and Cham, Rakie and Chan, Kevin C.,
"Widespread brain reorganization perturbs visuomotor coordination in early glaucoma," , no.
(October 2019),
http://hdl.handle.net/10342/8367 (accessed
May 21, 2024).
AMA:
Trivedi, Vivek, Bang, Ji Won, Parra, Carlos, Colbert, Max K., O’Connell, Caitlin, Arshad, Ahmel, Faiq, Muneeb A., Conner, Ian P., Redfern, Mark S., Wollstein, Gadi, Schuman, Joel S., Cham, Rakie, Chan, Kevin C..
Widespread brain reorganization perturbs visuomotor coordination in early glaucoma. .
October 2019;
():
.
http://hdl.handle.net/10342/8367. Accessed
May 21, 2024.
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