Internal Medicine: Recent submissions
Now showing items 1-20 of 26
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Methods, systems and computer program products for visualizing anatomical structures and blood flow and perfusion physiology using imaging techniques
(2016-04-21)Methods for combining anatomical data and physiological data on a single image are provided. The methods include obtaining an image, for example, a raw near-infrared (NIR) image or a visible image, of a sample. The image ... -
Multi-spectral physiologic visualization (MSPV) using laser imaging methods and systems for blood flow and perfusion imaging and quantification in an endoscopic design
(2017-08-28)Multispectral imaging systems are provided including a first light source having a first wavelength configured to image a sample; a second light source, different from the first light source, having a second wavelength, ... -
The Tumor Suppressive Effects of T Cell Death-Associated Gene 8 in Blood Cancers
(East Carolina University, 2017-03-16)In the early twentieth century Otto Warburg recognized a metabolic phenomenon that transpired in cancer cells, currently known as the Warburg Effect. Warburg discovered cancer cells favor glycolysis rather than oxidative ... -
Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells
(2016-07-26)Abstract Background Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased ... -
Postpartum spontaneous dissection of the first obtuse marginal branch of the left circumflex coronary artery causing acute coronary syndrome: a case report and literature review
(2013)Spontaneous coronary artery dissection (SCAD) is a very rare cause of acute coronary syndromes in young otherwise healthy patients with a striking predilection for the female gender. The pathological mechanism has not been ... -
Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
(2015-05)Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect”, commonly ... -
Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach
(2012-06)In the post-genome era, high throughput gene expression profiling has been successfully used to develop genomic biomarker panels (GBP) that can be integrated into clinical decision making. The development of GBPs in the ... -
MicroRNA profiling in the left atrium in patients with non-valvular paroxysmal atrial fibrillation
(2015-08)Background We aimed to identify the miRNA expression profiles in left atrial appendage, with the intention of identifying miRNAs that were significantly associated with non-valvular paroxysmal AF. Methods The RNA ... -
Feminizing Adrenal Carcinoma Presenting with Heart Failure and Ventricular Tachycardia
(2012)We present a case of feminizing adrenal carcinoma with severe elevation in serum estradiol and otherwise unexplained congestive heart failure with ventricular arrhythmia and review the literature on feminizing adrenal ... -
Granulocytic Sarcoma of the Male Breast in Acute Myeloblastic Leukemia with Concurrent Deletion of 5q and Trisomy 8
(2012)We describe a unique case of Granulocytic Sarcoma (GS) in a male, who presented to us with a painless right breast mass without any prior history of Leukemia. GS is an extramedullary tumor of myeloproliferative precursors ... -
Bouveret's Syndrome with Severe Esophagitis and a Purulent Fistula
(2014-04)Bouveret's syndrome is a rare variant of gallstone ileus with an overall incidence of 1–3%. It is a rare cause of gastric outlet obstruction resulting from the passage and impaction of a large gallstone through a ... -
The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
(2013)BACKGROUND: Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products ... -
Prolactin and Dehydroepiandrosterone Levels in Women with Systemic Lupus Erythematosus: The Role of the Extrapituitary Prolactin Promoter Polymorphism at −1149G/T
(2015)stemic lupus erythematosus (SLE) has shown an association with high levels of prolactin, low levels of dehydroepiandrosterone (DHEA), and induction of inflammatory cytokines in the serum of patients with the disease. This ... -
Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value
(2015)Long noncoding RNAs (lncRNAs) have recently been found to play important roles in various cancer types. The elucidation of genome-wide lncRNA expression patterns in metastatic nasopharyngeal carcinoma (NPC) could reveal ... -
Osteomyelitis Infection of Mycobacterium marinum: A Case Report and Literature Review
(2014-12)Mycobacterium marinum (M. marinum) is a ubiquitous waterborne organism that grows optimally at temperatures around 30°C. It is a nontuberculous Mycobacterium found in nonchlorinated water with worldwide prevalence. It is ... -
The transneuronal spread phenotype of herpes simplex virus type 1 infection of the mouse hind footpad.
(East Carolina University, 1997-03)The mouse hind footpad inoculation model has served as a standard laboratory system for the study of the neuropathogenesis of herpes simplex virus type 1 (HSV-1) infection. The temporal and spatial distribution of viral ... -
MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.
(East Carolina University, 1995-04)Increased protein kinase C (PKC) activity in malignant breast tissue and positive correlations between PKC activity and expression of a more aggressive phenotype in breast cancer cell lines suggest a role for this signal ... -
Correction:Peer chart audits: A tool to meet Accreditation Council on Graduate Medical Education (ACGME) competency in practice-based learning and improvement
(East Carolina University, 2007-07-27)Background: The Accreditation Council on Graduate Medical Education (ACGME) supports chart audit as a method to track competency in Practice-Based Learning and Improvement. We examined whether peer chart audits performed ...