Browsing Pharmacology and Toxicology by Author "DeWitt, Jamie C."
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Association of Perfluoroalkyl Substances, Bone Mineral Density, and Osteoporosis in the U.S. Population in NHANES 2009-2010
Khalil, Naila; Chen, Aimin; Lee, Miryoung; Czerwinski, Stefan A.; Ebert, James R.; DeWitt, Jamie C.; Kannan, Kurunthachalam (2015-06)Background Perfluoroalkyl substances (PFASs), including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), are detectable in the ... -
Breaking Patterns of Environmentally Influenced Disease for Health Risk Reduction: Immune Perspectives
Dietert, Rodney R.; DeWitt, Jamie C.; Germolec, Dori R.; Zelikoff, Judith T. (2010-08)Diseases rarely, if ever, occur in isolation. Instead, most represent part of a more complex web or “pattern” of conditions that are connected via underlying biological mechanisms and processes, emerge across a lifetime, ... -
EARLY LIFE STRESS AND PHARMACEUTICAL POLLUTANTS: DEVELOPMENTAL TOXICITY OF EMERGING AQUATIC CONTAMINANTS IN A MODEL TERRESTRIAL SPECIES
Meadows, Jacqueline Ruth (East Carolina University, 2019-07-18)Trace amounts of pharmaceutical and personal care products are plaguing water sources around the globe, and with no current regulations, these emerging contaminants pose a threat to environmental and human health. While ... -
Environmental risk factors for autism
Dietert, Rodney R.; Dietert, Janice M.; DeWitt, Jamie C. (2010-04)Autism is a devastating childhood condition that has emerged as an increasing social concern just as it has increased in prevalence in recent decades. Autism and the broader category of autism spectrum disorders are among ... -
Health effects following subacute exposure to geogenic dust collected from active drainage surfaces (Nellis Dunes Recreation Area, Las Vegas, NV)
DeWitt, Jamie C.; Buck, Brenda J.; Goossens, Dirk; Teng, Yuanxin; Pollard, James; McLaurin, Brett T.; Gerads, Russell; Keil, Deborah E. (2017-12-08)The specific health effects of directinhalation of fine minerogenic dusts generated by natural soil surfaces remain poorly known and relatively little researched. To learn more about this exposure and its contribution to ... -
The immune and neurological impacts of developmental Bisphenol A exposure in a C57bl/6 mouse model
Franklin, Jason Neil (East Carolina University, 2014)Environmental exposure to exogenous agents during critical time points of development may be associated with the onset of deleterious effects, including immune and neurological disorders. Numerous studies have shown that ... -
INFLUENCE OF PHYSICOCHEMICAL PROPERTIES OF SILVER NANOPARTICLES ON MAST CELL AND MACROPHAGE UPTAKE AND ACTVATION: ROLE OF SCAVENGER RECEPTOR B1
Aldossari, Abdullah Ali (East Carolina University, 2018-04-09)Silver nanoparticles (AgNPs) are widely used in consumer products and the medical field for their antimicrobial properties. Some studies reported toxic effects of AgNPs but cellular uptake of AgNPs and AgNP-induced ... -
Invited Perspective: Key Characteristics as a Starting Point for Improved Hazard Identification of Immunotoxic Agents
DeWitt, Jamie C.; Walker, Lauren M. (2022-10-06) -
Microglial dysfunction as an early susceptibility to Alzheimer's disease: the exacerbating role of developmental toxicity
VonderEmbse, Annalise Noelle (East Carolina University, 2017-07-25)The association between perturbations to neuroimmune development and susceptibility to adult neurodegenerative diseases, like Alzheimer's disease (AD), may undersore a putative pathogenic role for gradual microglial ... -
Perfluorooctanoic acid-induced developmental cardiotoxicity in an avian model
Jiang, Qixiao (East Carolina University, 2013)Perfluorooctanoic acid (PFOA) is a synthetic chemical used in polyfluormer production. It is a widespread environmental contaminant and is known to induce developmental toxicity in rodent models. As several related compounds ...