Browsing by Author "Biochemistry and Molecular Biology"
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Post-Transcriptional Regulation of mRNA Metabolism during Differentiation of 3T3-L1 Cells: Role of HuR
Karschner, Vesna Ann (East Carolina University, 2010)Our studies address early control points in the differentiation process that are necessary for expression as well as the maintenance of the adipocyte phenotype. We have focused on the post-transcriptional regulation of ... -
Regulation of Transglutaminase 2 structure and function by Ca²⁺ and [alpha]-synuclein
Viscomi, Jessica Sofia (East Carolina University, 2016-07-14)Transglutaminase 2 (TG2) catalyzes the Ca2+-dependent transamidation of protein substrates between glutamine and lysine residues by formation of an N[epsilon]-([gamma]-L-glutamyl)-L-lysine isopeptide bond. The Ca2+-dependent ... -
Relationship of N-glycans to Neuronal Dysfunction
Whitman, Austin A (East Carolina University, 2019-06-07)N-glycosylation is important in regulating protein activity and serves several vital roles contributing to protein folding, protein assembly, stability, and interactions. Changes in branching of N-glycans are linked to ... -
Resolving the Role of POU1F1 in Human Growth Hormone Locus Activation
Hunsaker, Tamra Leigh (East Carolina University, 2012)The human growth hormone gene ( hGH-N) is regulated by a distal locus control region (LCR) composed of five deoxyribonuclease I hypersensitive sites (HSs). The region encompassing HSI and HSII contains the predominant ... -
Retinoids Potentiate Clinically Relevant Cellular Responses through RARα/RXR Nuclear Receptor Synergism in Cutaneous T Cell Lymphoma
Wang, Lei (East Carolina University, 2015-12-15)The heterogeneity of cutaneous T cell lymphoma (CTCL) has stifled treatment options and hindered cure development. Despite the heterogeneous nature of CTCLs, a hallmark of all variants is malignant T cell infiltration of ... -
Selective Recruitment of Germ Cell mRNAs by eIF4 Factors
Friday, Andrew J. (East Carolina University, 1/13/16)During germ line development critical steps in the proliferation and differentiation of stem cells into oocytes and sperm are regulated by mRNA translational control. This regulation changes the subset of proteins being ... -
The C-terminus of Troponin T Modulates Calcium Regulation of Actin-Myosin Interactions
Johnson, Dylan James (East Carolina University, 2019-05-02)The highly conserved terminal fourteen C-terminal residues of troponin T play a novel role in the regulation of striated muscle contraction. Elimination of the terminal fourteen residues of the C-terminal region of troponin ... -
The Influence of Diet-Induced Obesity and N-3 Fatty Acids on the Cardiac Mitochondrial Phospholipidome and Respiratory Activity
Robison, E. Madison (East Carolina University, 2017-08-16)Cardiac mitochondrial phospholipids, notably cardiolipin (CL), regulate inner mitochondrial membrane (IMM) organization and protein function, particularly the enzymes associated with respiration. In a range of metabolic ... -
THE ROLE OF N6-METHYLADENOSINE IN HYPOXIA AND CELLULAR TRANSFORMATION
Fry, Nate J. (East Carolina University, 2017-11-29)Cancer is a prevalent disease that affects millions of people each year across the globe. In an effort to find therapies to the many types of cancers, regulation of protein expression through transcription and translation ... -
Understanding the Molecular Mechanisms that Contribute to Parkinson’s Disease: Defining the Role of Ca2+ in TG2: α-synuclein Macromolecular Complex Assembly
Washington, James (East Carolina University, 2018-12-10)Transglutaminase 2 (TG2) is an allosteric enzyme ubiquitously expressed in human tissue. This versatile enzyme has both Ca2+ -dependent, transamidase and GTPase activities. TG2's Ca2+ -dependent transamidase activity is ... -
The unique roles of IFE-1, a germline-specific isoform of eukaryotic translation factor 4E, during gametogenesis
Henderson, Melissa Anne (East Carolina University, 2009)Fertility and embryonic viability are measures of efficient germ cell growth and differentiation. During oogenesis, spermatogenesis and embryogenesis cells initially proliferate then differentiate into specific tissues. ...