Browsing by Author "Biomedical Sciences"
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Macrophage Regulation in the Murine Inflammatory Response
Shine, Sherri M (East Carolina University, 2018-08-30)The development of acute and chronic liver disease is a complex condition involving the dysregulation of hepatic metabolism and the accumulation of critical immune cells; specifically, the recruitment and activation of ... -
Matrix Metalloproteinase 12 is Critical for Granuloma Formation in the Murine Model of Granulomatous disease
Neequaye, Nicole N (East Carolina University, 2019-08-16)Matrix Metalloproteinase 12 (MMP12) is a protein produced primarily by alveolar macrophages that degrades elastin in the extracellular matrix (ECM) and enables infiltration of immune cells that participate in the inflammatory ... -
Molecular Histology of EphrinA1 Expression in Mouse Heart Visualized Molecular Histology of EphrinA1 Expression in Mouse Heart Visualized with MALDI-MSI
Parks, Justin C. (East Carolina University, 2018-07-25)EphrinA1 is a tyrosine kinase receptor localized in the cellular membrane of healthy cardiomyocytes, the expression of which is lost upon myocardial infarction (MI). Intra-cardiac injection of the recombinant form of ... -
Notch 3 Affects Chemoresistance in Colorectal Cancer via DNA Base Excision Repair Enzymes
Khan, Azeem (East Carolina University, 2017-07-28)Approximately 1.2 million cases of colorectal cancer (CRC) arise each year, and 40-50% of CRC patients will reach metastasis. The Notch pathway is known to be dysregulated in CRC, and its relationship with DNA repair ... -
Notch Signaling Mediates Drug Resistance in Colorectal Cancer Cells via Effects on DNA Repair Proteins
George, Dennis (East Carolina University, 2016-07-25)Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States and the third most commonly diagnosed cancer in men and women. Despite tremendous progress in diagnosis, prevention, and treatment ... -
Novel Function of PUF Proteins and Their Partners in Spermatogenesis and Spermatocyte-Derived Germline Tumors in Caenorhabditis elegans
Park, Youngyong (East Carolina University, 2022-04-27)Conserved PUF (Pumilio and FBF) proteins repress the translation by binding to its target mRNA 3' untranslated region (3'UTR). C. elegans has 11 PUF proteins. Among them, we focused on two FBFs (FBF-1 and FBF-2) and PUF-8. ... -
Peroxisome Proliferator-Activated Receptor Gamma Deficiency Promotes a T Lymphocyte Response in a Murine Model of Chronic Pulmonary Sarcoidosis
Sanderford, Victoria L (East Carolina University, 2019-07-03)Sarcoidosis is a chronic granulomatous disease of unknown etiology. Previous studies from our lab have shown a deficiency of the nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPAR[gamma]) ... -
Predicting HBZ Interaction with BATF3 Enhancer Regions Through ChIP-seq
Luke, Mikayla (East Carolina University, 2021-05-28)Human Lymphotropic Virus Type 1 (HTLV-1) is a complex retrovirus that causes Adult T-cell Leukemia (ATL), an often-fatal form of cancer characterized by uncontrolled proliferation of infected CD4+ T-cells. The viral protein ... -
Proposed regulatory role of noncatalytic Adams in ectodomain shedding
Hoggard, Jason Andrew (East Carolina University, 2015)Members of the ADAM (A Disintegrin And Metalloprotease) protein family uniquely exhibit both proteolytic and adhesive properties. Specifically, ADAMs catalyze the conversion of cell-surface proteins to soluble, biologically ... -
PUF-8 and MPK-1: Genetic and Chemical Control of Spermatocyte Dedifferentiation in Caenorhabditis elegans
Gaddy, Matthew A. (East Carolina University, 2021-05-03)Stem cells face a number of major fate decision during their development: the decision to self-renew or differentiate, and then whether to remain differentiated or dedifferentiate, as occurs in some oncogenesis. A regulatory ... -
Pulmonary Pathologies Following Inhalation of Multi-Walled Carbon Nanotubes at Occupational Levels
Phipps, Marshal Anthony, Jr. (East Carolina University, 1/13/16)Multi-walled carbon nanotubes (MWCNT) are a nanomaterial that is growing in use and popularity. The health effects of occupational pulmonary exposure to MWCNT are currently unknown. The goals of this study were to build a ... -
Resolution of Chronic Granulomatous Inflammation and Fibrosis in a Murine Model of Sarcoidosis
Bhalla, Sophia (East Carolina University, 2021-07-14)Sarcoidosis is a chronic granulomatous disease of unknown cause. Granulomas resolve within 12-26 months in 50% of cases without therapy while 30% of patients have chronic disease that progresses to pulmonary fibrosis. The ... -
Role of Dopamine Receptor 3 in Cardiac Fibrosis
Byrne, Shannon Elizabeth (East Carolina University, 2021-12-20)Dopamine receptors are known to exist primarily in the central nervous system and have been extensively studied there. However, other organ systems in the periphery, such as the kidney, have been shown to express these ... -
Role of Macrophage Polarization and Apolipoprotein E in Granuloma Resolution
Ogburn, David R (East Carolina University, 2021-07-06)Sarcoidosis is a chronic disease characterized by the development and accumulation of granulomas. Through multiwall carbon nanotube (MWCNT) instillation of C57 Bl/6 (wild-type) mice, we have established a murine model that ... -
Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer.
Fender, Alexander W. (East Carolina University, 2015)Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States. Surgical resection and combination chemotherapy are often used for treatment, but in later stages of the disease, ... -
SPINAL CORD REFLEXES IN A BRAIN-IRON DEFICIENT MODEL OF RESTLESS LEGS SYNDROME: ROLE OF DOPAMINE AND ADENOSINE RECEPTORS
Woods, Sydney (East Carolina University, 2021-05-04)Restless Legs Syndrome (RLS) is a sensorimotor disorder that severely disrupts sleep. RLS patients regularly present with a condition known as Brain Iron Deficiency (BID), and BID is commonly associated with altered dopamine ... -
Targeting Kremen1 Downregulation with RVG-9R/siRNA Complexes in the Triple-Transgenic Mouse Model of Alzheimer’s Disease
Baker, Kelly E. (East Carolina University, 2017-07-19)Alzheimer's disease (AD) is a progressive disease characterized by cognitive decline and memory loss. Memory loss observed in AD results from the loss of neurons and synapses which may be caused by the disruption of the ... -
TGF-β Signaling, Via Smad3, Mediates Notch Pathway-Induced Stemness and Epithelial to Mesenchymal Transition in Colon Cancer Cells
Clark, Alexander G. (East Carolina University, 2017-08-21)Late stage colorectal cancer (CRC) remains a challenging disease to treat due to several factors including stemness and epithelial to mesenchymal transition (EMT). Dysfunctional signaling pathways in CRC contribute to these ... -
The Circadian Rhythm and its Role in the Dynamic Dopamine Neuron Phenotype
Barker, Samantha (East Carolina University, 2021-05-04)The circadian rhythm is strongly implicated in many neuropsychiatric and neurodegenerative disorders, all of which are associated with altered dopamine (DA) neurotransmission in the substantia nigra and ventral tegmental ... -
The effects of high-fat diet induced insulin resistance on cardiac structure, function, and lipid profile
Sarathy, Brinda (East Carolina University, 2021-04-23)Intracardiac injection of recombinant EphrinA1-Fc immediately following coronary artery ligation in mice reduces infarct size in both reperfused and non-reperfused myocardium. These protective effects occurred via modulation ...