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Now showing items 2213-2232 of 10631
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Cystic Fibrosis Virtual Patient Advocacy
(2021-07-27)Cystic Fibrosis is a rare life-limiting genetic disorder that affects 30,000 people in the United States. The CF population has seen an increase in their life expectancy as new research, therapies and technology has ... -
CYTOKINE-BASED FUSION PROTEINS FOR TREATMENT OF MULTIPLE SCLEROSIS
(2014-12-30)The present invention provides fusion proteins including an autoimmune antigen, an allergen antigen or an alloantigen, and an anti-inflammatory cytokine. Compositions and meth ods including the fusion proteins are also provided. -
Cytokine-Neuroantigen Fusion Proteins as a New Class of Tolerogenic, Therapeutic Vaccines for Treatment of Inflammatory Demyelinating Disease in Rodent Models of Multiple Sclerosis
(2012-08)Myelin-specific induction of tolerance represents a promising means to modify the course of autoimmune inflammatory demyelinating diseases such as multiple sclerosis (MS). Our laboratory has focused on a novel preclinical ... -
Cytokine-neuroantigen fusion proteins as a new class of tolerogenic, therapeutic vaccines for treatment of inflammatory demyelinating disease in rodent models of multiple sclerosis
(2012-08-20)Myelin-specific induction of tolerance represents a promising means to modify the course of autoimmune inflammatory demyelinating diseases such as multiple sclerosis (MS). Our laboratory has focused on a novel preclinical ... -
Cytokines and neuroantigens for treatment of immune disorders
(2017-05-10)The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. ... -
Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
(2015-01)Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited colony ... -
Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
(2014)Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited ... -
Cytotoxic and Pathogenic Properties of Klebsiella oxytoca Isolated from Laboratory Animals
(2014-07)Klebsiella oxytoca is an opportunistic pathogen implicated in various clinical diseases in animals and humans. Studies suggest that in humans K. oxytoca exerts its pathogenicity in part through a cytotoxin. However, cytotoxin ... -
Daily and season-long fantasy sports participation and gambling-related problems among a sample of college students at three universities
(2018)Traditionally, fantasy sports have been played in season-long leagues, but recently daily fantasy sports (DFS) have emerged, allowing participants to play fantasy contests over shorter periods of time. Although participating ... -
Daily precipitation distributions over the intra-Americas sea and their interannual variability
(2012-05-30)The seasonal (March to October) and interannual variability of the cumulative distribution function (CDF) of precipitation is examined for Meso-America, the eastern Pacific and western Atlantic, commonly referred to as the ... -
Daily walks can improve digestion, chronic conditions
(2023-09-13)This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column is "Daily walks can improve digestion, chronic conditions." -
Damage control surgery: It's evolution over the last 20 years
(2012-03-15)In less than twenty years, what began as a concept for the treatment of exsanguinating truncal trauma patients has become the primary treatment model for numerous emergent, life threatening surgical conditions incapable ... -
The Dangers of Online Shopping
(2022-04-19)Online shopping has become a crucial part of society in today’s age of technology. Many of us face identity theft, credit card theft, and more just by putting our personal information on shopping websites. Downloading ...