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Murine Pancreatic Adenocarcinoma Reduces Ikaros Expression and Disrupts T Cell Homeostasis
(2015-01)Background Maintenance of T cell immune homeostasis is critical for adequate anti-tumor immunity. The transcription factor Ikaros is essential for lymphocyte development including T cells. Alterations in Ikaros expression ... -
Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment
(2015-05)Recent strategies to treat peripheral arterial disease (PAD) have focused on stem cell based therapies, which are believed to result in local secretion of vascular growth factors. Little is known, however, about the role ... -
Muscle stiffness as a cause of reduced muscle volume - a reliability study
(2014-12)A leading cause of impairment in elderly individuals is sarcopenia, the progressive deterioration of muscle size and strength, which ultimately limits muscle functionality. The loss of muscular strength is directly correlated ... -
Muscle Work Discrepancy during Incline and Decline Running at Three Speeds
(East Carolina University, 2009)Introduction: Previous research has explored muscle function during gait and this work has shown that more positive mechanical muscle work is produced in gait tasks that primarily raise the center of mass (incline gait ... -
Muscle work is biased toward energy generation over dissipation in non-level running
(East Carolina University, 2008-12-05)This study tested the hypothesis that skeletal muscles generate more mechanical energy in gait tasks that raise the center of mass compared to the mechanical energy they dissipate in gait tasks that lower the center of ... -
Muscles do more positive than negative work in human locomotion
(East Carolina University, 2007-10)Muscle work during level walking and ascent and descent ramp and stairway walking was assessed in order to explore the proposition that muscles perform more positive than negative work during these locomotion tasks. Thirty ... -
Music Discovery Requirements Document
(2012-02-24)The world of discovery in general and of library discovery in particular is changing rapidly today. FRBR, RDA, discovery tools, and faceted browsing are key factors related to these changes in the way our users encounter ... -
Music Middle-School Energizers Classroom-based Physical Activities The way teachers integrate physical activity with academic concepts
(2006)Middle School Energizers are classroom-based physical activities that integrate physical activity with academic concepts. The Middle School Energizers were developed by a team from the Activity Promotion Laboratory at East ... -
Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response
(2012-09)The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Certain components of these pathways, RAS, NF1, BRAF, ... -
A Müllerian mimicry ring in Appalachian millipedes
(East Carolina University, 2009-06-16)Few biological phenomena provide such an elegant and straightforward example of evolution by natural selection as color mimicry among unrelated organisms. By mimicking the appearance of a heavily defended aposematic ... -
N-3 polyunsaturated fatty acids differentially enhance B-cell mediated immunity in lean and obese mice
(East Carolina University, 2014)Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are bioactive n-3 polyunsaturated fatty acids (PUFAs) in fish oil that exert immunomodulatory effects. The general paradigm suggests n-3 PUFAs exert immunosuppressive ... -
NADPH Oxidase as a Mechanistic Link Between Erectile Dysfunction, Peripheral, and Coronary Endothelial Dysfunction in Obesity
(East Carolina University, 2012)Cardiovascular complications involving both microvascular and macrovascular tissues are the major cause of morbidity and mortality in obese patients. Clinical and epidemiological studies suggest that erectile dysfunction ... -
NAGPRA's Impact on North Carolina and the Southeast : Research on the Research
(East Carolina University, 2010)This thesis researches the impact of the Native American Grave Protection and Repatriation Act (NAGPRA) on academic bioarchaeological research in the southeastern United States and North Carolina. Scholarly journals, ... -
THE NAMING OF THE PARTS : AN ASSOCIATIVE STUDY OF WRITNG [sic] RELEVANT KNOWLEDGE, WORKING MEMORY, AND CURRICULUM POTENTIAL
(East Carolina University, 2013)This study was designed to identify and to test a model to assist educational leaders to develop quantifiable assessments of student learning to meet the requirements for institutional assessment by external stakeholders ... -
Narrative, Identity, and Sense of Place Discourse : Woman's Club of Fayetteville, North Carolina, 1906-1912
(East Carolina University, 2012)This dissertation analyzes the discourse (the narratives) used by members of the Woman's Club of Fayetteville in Fayetteville, North Carolina, from 1906 through 1912, as they (1) saved the Market House from destruction and ... -
Nascent Myth
(East Carolina University, 2010)This is a written report of a creative thesis. The body of work presented in "Nascent Myth" evolved from personal exploration regarding myth and spirituality. Birds are used as the unifying element to present several ... -
Natal Origin of Central Southern Management Area, North Carolina Striped Bass, Inferred from Otolith Microchemistry
(East Carolina University, 2013)Striped bass (Morone saxatilis) is an important commercial and game fish throughout North Carolina coastal waters. These fish have spawning populations present in all of the state's coastal rivers, however populations south ... -
National Athletic Trainers' Association Position Statement: Lightning Safety for Athletics and Recreation
(East Carolina University, 2000-10)Objective: To educate athletic trainers and others about the dangers of lightning, provide lightning-safety guidelines, define safe structures and locations, and advocate prehospital care for lightning-strike victims. ... -
A National Needs Analysis of Sudden Cardiac Arrest Survivors
(East Carolina University, 2015)Psychosocial outcomes of sudden cardiac arrest survivors have generally been studied in single center samples. Large, nationally representative patient surveys may offer different perspectives. The aim of the current ...