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AMP Deaminase 3 in Skeletal Muscle Atrophy: Regulation of Protein Degradation and Contractile Performance
(East Carolina University, 2015-11-23)Skeletal muscle atrophy is characterized by depressed cellular energetics, increased rates of protein degradation, contractile deficits and loss of muscle mass. A potential regulator of these impairments is the metabolic ... -
AMP Deaminase 3 knockout mice and loss of mitochondrial proteins and enzyme activity during denervation atrophy
(East Carolina University, 2018-07-17)Muscle atrophy leads to decrements in muscle function, partly attributable to decreased mitochondrial content. One controller of mitochondrial content is AMP-activated protein kinase (AMPK), which when bound by AMP activates ... -
AMP Deaminase 3 overexpression regulates cellular energetics and signaling for PGC-1α activation.
(East Carolina University, 2017-06-02)Skeletal muscles undergoing atrophy have decreased [ATP], PGC-1[alpha] expression, and mitochondrial content. This combination of findings is unexpected because decreased [ATP] is often associated with greater [AMP] and ... -
AMP-activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle
(East Carolina University, 2009-05-01)One characteristic of aging skeletal muscle is a decline in mitochondrial function. Activation of AMP-activated protein kinase (AMPK)occurs in response to an increased AMP/ATP ratio,which is one potential result of ... -
AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise
(East Carolina UniversityEast Carolina University, 2008-12-15)5 -AMP-activated protein kinase(AMPK)is a metabolic fuel sensor that monitors cellular energy charge, while the vasculature is important for maintaining cellular energy homeostasis. Mice with muscle-specific inactive AMPK ... -
Amyloid-beta peptide A beta p3-42 affects early aggregation of full-length A beta 1-42
(East Carolina University, 2009-05)The major amyloid beta (Aβ) peptides found in the brain of familial and late onset Alzheimer’s disease include the full-length Aβ1-42 and N-terminally truncated, pyroglutamylated peptides Aβp3-42 and Aβp11-42. The ... -
AN ALL HAZARDS, ALL AGENCIES, ALL PEOPLE APPROACH TO ASSESS LOCAL- LEVEL HOUSEHOLD EMERGENCY PREPAREDNESS AND COMMUNITY DISASTER RESILIENCE
(East Carolina University, 2022-11-30)Problem: Given the increasing frequency, intensity, and severity of disasters, and a gap in disaster research examining the interdependent systemic relationships between individuals and communities, we urgently need to ... -
AN ANALYSIS OF A PLAN TO IMPROVE THE GRADUATION RATES IN JOHNSTON COUNTY SCHOOLS
(East Carolina University, 2015-12-10)There have been limited qualitative case studies exploring effective strategies designed to improve graduation rates in rural school districts. Specifically, few studies have presented information based solely upon the ... -
AN ANALYSIS OF A STONE ARTIFACT CACHE FROM THE SHELOR SITE (31MG2051) IN MONTGOMERY COUNTY, NORTH CAROLINA
(East Carolina University, 2016-07-25)Prehistoric artifact cache discoveries are poorly understood archaeological phenomena. A few such occurrences consisting of groups of stone artifacts buried in forgotten underground pits are known in North Carolina. This ... -
AN ANALYSIS OF ALFRED SCHNITTKE'S POLYSTYLISM IN HIS STRING QUARTET NO. 3 (1983)
(East Carolina University, 2018-07-30)The study of polystylism and its role in the history of music is a relatively new idea; Alfred Schnittke is often regarded as the first true proponent of the term, and the bulk of his compositional output did not begin ... -
An Analysis of Dietary Habits of Young Adults Seeking Weight Loss and the Feasibility of a Modified Monitoring System Using Mobile Technology in Young Adults
(East Carolina University, 2016-04-29)With rates of overweight and obesity at the highest in recorded history, for the first time, it is expected that obese young adults will have a significantly lessened life expectancy compared to their non-obese counterparts ... -
AN ANALYSIS OF PUBLIC OPINION ON HUMAN TRAFFICKING LEGISLATION IN NORTH CAROLINA
(East Carolina University, 2022-12-08)Human trafficking presents an enormous issue for the United States and the state of North Carolina. Current legislative frameworks for labor and sex trafficking exist on the federal and state level, however the current ... -
An Analysis of Publicly Available Health Education Materials Designed for Migrant Farm Workers
(East Carolina University, 2021-05-28)BACKGROUND: In the United States, there are more than 3 million migrant or seasonal farm workers each year. The lack of legal protections, low pay, and often-dangerous work conditions lead to serious health inequities for ...