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Now showing items 5463-5482 of 10630
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Investigation of Platinum-Catalyzed Acylation of 2-Aryloxypyridines via C-H Activation and Functionalization
(East Carolina University, 2022-07-12)Transition metal catalyzed C-H activation and functionalization reactions allow synthetic chemists to break the normally unreactive carbon-hydrogen bond and create a new and useful carbon-oxygen, carbon-nitrogen, carbon-halogen, ... -
Investigation of Platinum-Catalyzed Acylation of 2-Aryloxypyridines via C-H Activation and Functionalization
(East Carolina University, 2022-07-12)Transition metal catalyzed C-H activation and functionalization reactions allow synthetic chemists to break the normally unreactive carbon-hydrogen bond and create a new and useful carbon-oxygen, carbon-nitrogen, carbon-halogen, ... -
Investigation of possible driving forces on counter-intuitive thermal collapse of intrinsically disordered proteins
(East Carolina University, 2016-08-18)Intrinsically disordered proteins are an emerging class of proteins that contain no secondary or tertiary structure. Through bioinformatics studies it has been predicted that a third of the human proteome consists of ... -
Investigation of Safety Culture among Young Workers
(East Carolina University, 2019-04-30)According to the Occupational Safety and Health Administration (OSHA), young workers whose ages range from 14 to 24 and are interested in finding different jobs during the summer or during the school year are considered ... -
Investigation of the Anatomical and Physiological Changes Following the Use of a Pedicled Buccal Fat Pad Graft During Primary Palatoplasty
(East Carolina University, 2019-07-19)Children with cleft palate typically undergo primary surgery between 6-12 months of age to close the cleft in the palate and create proper muscle function for elevation and retraction of the velum for speech. About one ... -
AN INVESTIGATION OF THE TAPHONOMIC EFFECTS OF ANIMAL SCAVENGING
(East Carolina University, 2014)Numerous environmental and human-induced variables that affect decomposition can cloud accurate estimations of the postmortem interval (PMI). For instance, scavenging animals can remove soft tissue and disarticulate and ... -
Investigation of the Zinc binding region of Prothymosin-alpha : A spectroscopic and thermodynamic approach to study metal binding in Intrinsically disordered proteins
(East Carolina University, 2014)The goal of this study is to provide a deeper insight into how metals bind intrinsically disordered proteins (IDPs) by taking zinc binding to prothymosin-alpha as a case study. The involvement of metals in several diseases ... -
Investigations into the Oldest Standing Structure in North Carolina
(East Carolina University, 1/13/16)In 2010, Steven and Linda Lane purchased 304 East Queen Street, Edenton, North Carolina. While renovating the structure they discovered that it was much older than previously thought. The results of a dendrochronology ... -
Investigations into the roles of bacteroides fragilis thioredoxins during the oxidative stress response
(East Carolina University, 2011)The Gram-negative Bacteroides fragilis is the most frequently isolated bacterium from anaerobic infections. Native to the human intestinal tract, it serves a symbiotic role breaking down complex polysaccharides and ... -
Investigations of the Brevard Fault zone and Tugaloo Terrane adjacent to the Grandfather Mountain Window, North Carolina
(East Carolina University, 2023-07-24)The Brevard Fault Zone adjacent to the Grandfather Mountain window, NC is interpreted to be a terrane boundary between Laurentian margin rocks and accreted rocks of the Tugaloo Terrane. Structural, geochemical, and ... -
Investigations Of The Impact Of Altered Auditory Feedback In-The-Ear Devices On The Speech Of People Who Stutter: Initial Fitting And Four-Month Follow-Up
(East Carolina University, 2004)Background: Self-contained ear-level devices delivering altered auditory feedback (AAF) for the application with those who stutter were only recently developed (Stuart et al. 2003). Aim: This paper examines the first ... -
Investigations Of The Impact Of Altered Auditory Feedback In-The-Ear Devices On The Speech Of People Who Stutter: One-Year Follow-Up
(East Carolina University, 2006)Purpose: This study examined objective and subjective measures of the effect of a self-contained ear-level device delivering altered auditory feedback (AAF) for those who stutter 12 months following initial fitting with ... -
Investors’ Perceptions of Potentially Fraudulent Environmental, Social, and Governance Disclosures
(East Carolina University, 2023-05-15)Investor’s Perceptions regarding Fraudulent Environment, Social, and Governance (ESG) Disclosures digs heavily into how important the validity of ESG disclosures are to potential and current investors of a well preforming ... -
Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy
(2011-07)Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based drugs is clearly important as these are frequently used therapeutic approaches. A signaling pathway often involved in chemo- and ... -
Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy
(2011-07-01)Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based drugs is clearly important as these are frequently used therapeutic approaches. A signaling pathway often involved in chemo- and ... -
The involvement of cap-independent mRNA translation in cell fate decisions
(East Carolina University, 2014)During cell stress many biochemical processes are shut down. For example, global mRNA translation initiation is inhibited due to the disruption of the cap-dependent mRNA recruitment mechanism. One specific example of ...