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Now showing items 7111-7130 of 10629
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Pharmacological Regulation of Neural Circuit Formation in hIPSC-Derived Neurons and ‘Mini-Brains’
(East Carolina University, 2018-07-20)Emerging evidence suggests that altered neural connectivity, particularly at the level of synaptic connections, contributes to the pathology of many neurodevelopmental and neurodegenerative diseases. For instance, post-mortem ... -
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer
(2019-12-01)PURPOSE: Oral mucositis (OM) remains a common, debilitating toxicity of radiation therapy (RT) for head and neck cancer. The goal of this phase IIb, multi-institutional, randomized, double-blind trial was to compare the ... -
Phenology in a Changing Environment: Assessing and Forecasting the Timing of the Spawning Migration of the Albemarle Sound and Roanoke River Stock of Striped Bass
(East Carolina University, 2022-07-19)The seasonal timing of key biological events (phenology), such as migrations, can vary greatly and have strong impacts on fisheries and their management. The Striped Bass (Morone saxatilis) population of the Roanoke River ... -
Phenology in a Changing Environment: Assessing and Forecasting the Timing of the Spawning Migration of the Albemarle Sound and Roanoke River Stock of Striped Bass
(East Carolina University, 2022-07-19)The seasonal timing of key biological events (phenology), such as migrations, can vary greatly and have strong impacts on fisheries and their management. The Striped Bass (Morone saxatilis) population of the Roanoke River ... -
A PHENOMENOLOGICAL STUDY OF FIVE HBCU CHANCELLORS IN ONE SOUTHEASTERN STATE
(East Carolina University, 2014)Founded out of necessity due to overt racism that kept Blacks out of higher education, HBCUs today find themselves in precarious positions to stay relevant in an academic field where PWIs compete for Black students. There ... -
Phenomenological Study of Transformative Learning in Conversion to the Catholic Faith
(East Carolina University, 2017-12-14)This research explored the phenomenon of learning transformation as it arises in the context of conversion to Catholicism. The theory of transformative learning describes a process of learning and reflection, in which an ... -
The Phenomenology of Impairment
(East Carolina University, 2014)This written research document supports The Phenomenology of Impairment, a mixed media installation consisting of three hundred and sixty-five self-portraits. This work was a part of a phenomenological exercise that ... -
Phenotypic and Genetic Divergence among Poison Frog Populations in a Mimetic Radiation
(2013-02-06)The evolution of Müllerian mimicry is, paradoxically, associated with high levels of diversity in color and pattern. In a mimetic radiation, different populations of a species evolve to resemble different models, which can ... -
Phenotypic and Genetic Divergence among Poison Frog Populations in a Mimetic Radiation
(2013)The evolution of Müllerian mimicry is, paradoxically, associated with high levels of diversity in color and pattern. In a mimetic radiation, different populations of a species evolve to resemble different models, which can ... -
The Philosophy of Happiness: A State of Being
(2014-12)Depression is a mental condition of dejection and can limit one’s energy and motivation to engage in life. The purpose of this Senior Honors Project is to develop a concept of happiness so that a better understanding of ... -
Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death.
(East Carolina University, 1995-10)Protein kinase C (PKC) modulates growth, differentiation, and apoptosis in a cell-specific fashion. Overexpression of PKC-a in MCF-7 breast cancer cells (MCF-7-PKC-a cell) leads to expression of a more transformed phenotype. ... -
The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients
(2010-06)The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling axis plays a central role in cell proliferation, growth, and survival under physiological conditions. However, aberrant PI3K/Akt/mTOR ... -
Phosphodiesterases regulate BAY 41-2272-induced VASP phosphorylation in vascular smooth muscle cells
(2012-02-07)BAY 41-2272 (BAY), a stimulator of soluble guanylyl cyclase, increases cyclic nucleotides and inhibits proliferation of vascular smooth muscle cells (VSMCs). In this study, we elucidated mechanisms of action of BAY in its ... -
Phosphodiesterases Regulate BAY 41-2272-Induced VASP Phosphorylation in Vascular Smooth Muscle Cells
(2012-02)BAY 41-2272 (BAY), a stimulator of soluble guanylyl cyclase, increases cyclic nucleotides and inhibits proliferation of vascular smooth muscle cells (VSMCs). In this study, we elucidated mechanisms of action of BAY in its ...