Browsing by Author "McCubrey, James A."
-
Nuclear Nox4 Interaction with Prelamin A is Associated with Nuclear Redox Control of Stem Cell Aging
McCubrey, James A. (2018-10-24) -
Nuclear Translocation of PKC is Associated with Cell Cycle Arrest and Erythroid Differentiation in Myelodysplastic Syndromes (MDSs)
McCubrey, James A. (2019-02-04) -
Oleocanthal Exerts Antitumor Effects on Human Liver and Colon Cancer Cells Through ROS Generation
McCubrey, James A. (2017-08) -
Overcoming resistance to molecularly targeted anticancer therapies: rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies
Tortora, Giampaolo; Bianco, Roberto; Daniele, Gennaro; Ciardiello, Fortunato; McCubrey, James A.; Ricciardi, Maria Rosaria; Ciuffreda, Ludovica; Cognetti, Francesco; Tafuri, Agostino; Milella, Michele (East Carolina University, 2007-06)Accumulating evidence suggests that cancer can be envisioned as a "signaling disease", in which alterations in the cellular genome affect the expression and/or function of oncogenes and tumour suppressor genes. This ... -
p53 and NGAL: dual regulatory roles in advanced prostate cancer
Chappell, William H. (East Carolina University, 2011)The development of prostate cancer from small regions of hyperplasia to invasive tumors requires genetic and epigenetic alterations of critical cellular components to aid in the development of cells more adapted for aberrant ... -
Pathobiology and Therapeutic Relevance of GSK-3 in Chronic Hematological Malignancies
McCubrey, James A.; Martelli, Alberto M.; Paganelli, Francesca; Evangelisti, Camilla; Chiarini, Francesca (2022-05-31) -
The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients
Martelli, Alberto M.; Evangelisti, Camilla; Chiarini, Francesca; McCubrey, James A. (2010-06)The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling axis plays a central role in cell proliferation, growth, and survival under physiological conditions. However, aberrant PI3K/Akt/mTOR ... -
PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer
Knostman, Katherin A. B.; McCubrey, James A.; Morrison, Carl D.; Zhang, Zhaoxia; Capen, Charles C.; Jhiang, Sissy M. (East Carolina University, 2007-07-25)Background: The sodium/iodide symporter (NIS) is a membrane glycoprotein mediating active iodide uptake in the thyroid gland and is the molecular basis for radioiodide imaging and therapeutic ablation of thyroid carcinomas. ... -
PI3K isoform inhibition associated with anti Bcr-Abl drugs shows in vitro increased anti-leukemic activity in Philadelphia chromosome-positive B-acute lymphoblastic leukemia cell lines
Ultimo, Simona; Simioni, Carolina; Martelli, Alberto M.; Zauli, Giorgio; Evangelisti, Camilla; Celeghini, Claudio; McCubrey, James A.; Marisi, Giorgia; Ulivi, Paola; Capitani, Silvano; Neri, Luca M. (2017-02-20)B-acute lymphoblastic leukemia (B-ALL) is a malignant disorder characterized by the abnormal proliferation of B-cell progenitors. Philadelphia chromosome-positive (Ph+) B-ALL is a subtype that expresses the Bcr-Abl fusion ... -
PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors
Lonetti, Annalisa; Cappellini, Alessandra; Spartà, Antonino Maria; Chiarini, Francesca; Buontempo, Francesca; Evangelisti, Camilla; Evangelisti, Cecilia; Orsini, Ester; McCubrey, James A.; Martelli, Alberto M. (2015-04)Class I phosphatidylinositol 3-kinases (PI3Ks) are frequently activated in T-cell acute lymphoblastic leukemia (T-ALL), mainly due to the loss of PTEN function. Therefore, targeting PI3Ks is a promising innovative approach ... -
PKR Regulates B56 alpha-mediated BCL2 Phosphatase Activity in Acute Lymphoblastic Leukemia-derived REH Cells
Ruvolo, Vivian R.; Kurinna, Svitlana M.; Karanjeet, Kul B.; Schuster, Todd F.; Martelli, Alberto M.; McCubrey, James A.; Ruvolo, Peter P. (East Carolina University, 2009-12-19)Protein phosphatase 2A (PP2A) is a heterotrimer comprising catalytic, scaffold, and regulatory (B) subunits. There are at least 21 B subunit family members. Thus PP2A is actually a family of enzymes defined by which B ... -
PLC-beta 1 regulates the expression of miR-210 during mithramycin-mediated erythroid differentiation in K562 cells
Bavelloni, Alberto; Poli, Alessandro; Fiume, Roberta; Blalock, William L.; Matteucci, Alessandro; Ramazzotti, Giulia; McCubrey, James A.; Cocco, Lucio; Faenza, Irene (2014-06)PLC-beta 1 (PLCβ1) inhibits in human K562 cells erythroid differentiation induced by mithramycin (MTH) by targeting miR-210 expression. Inhibition of miR-210 affects the erythroid differentiation pathway and it occurs to ... -
Preclinical Evaluation of the PI3K/Akt/mTOR Pathway in Animal Models of Multiple Sclerosis
McCubrey, James A. (2018-01-03) -
Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia
Fala, Federica; Blalock, William L.; Tazzari, Pier Luigi; Cappellini, Alessandra; Chiarini, Francesca; Martinelli, Giovanni; Tafuri, Agostino; McCubrey, James A.; Cocco, Lucio; Martelli, Alberto M. (East Carolina University, 2008-09)Constitutively activated AKT kinase is a common feature of T-cell acute lymphoblastic leukemia (T-ALL). Here, we report that the novel AKT inhibitor (2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2Hindazol-5-yl)pyridin-3-yl]oxypr ... -
A PTEN Inhibitor Displays Preclinical Activity Against Hepatocarcinoma Cells
McCubrey, James A. (2016) -
PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer
McCubrey, James A. (2017-02-21) -
Quantitative Phosphoproteome Analysis of Embryonic Stem Cell Differentiation Toward Blood
McCubrey, James A. (2015-03-26)