Browsing by Subject "Biology"
Now showing items 81-97 of 97
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Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer.
(East Carolina University, 2015)Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States. Surgical resection and combination chemotherapy are often used for treatment, but in later stages of the disease, ... -
The role of peroxisome proliferator-activated receptor-gamma in surfactant catabolism in the alveolar macrophage
(East Carolina University, 2009)Pulmonary alveolar proteinosis (PAP) is a lung disease characterized by surfactant accumulation in the alveolar spaces and alveolar macrophages. Although PAP is rare, surfactant abnormalities occur in many lung diseases ... -
The Role of Transcription Factors Snail and Slug in Cardiac Myofibroblasts
(East Carolina University, 2014)CCardiac fibrosis is a major facet contributing to cardiac dysfunction following a myocardial infarction. Persistent and excessive collagen deposition via cardiac myofibroblasts is the hallmark of cardiac fibrosis. Cardiac ... -
Spatial Ecology and Seasonal Habitat Use of the King Rail (Rallus elegans) along the Atlantic Coast
(East Carolina University, 2014)TThe King Rail (Rallus elegans) continues to experience population declines throughout its range. Due to its secretive nature and occupancy of densely vegetated marshes, little is known about the behavior and ecology of ... -
SPATIAL EXPRESSION OF MATRIX AND MATRIX RECEPTOR PROTEINS IN THE DEVELOPING SYNOVIAL JOINT
(East Carolina University, 2013)Little is understood about the complex spatial and temporal molecular interactions necessary to form a fully functional synovial joint. Understanding molecular pathways and signaling within the developing joint continues ... -
Spatio-Temporal Expression of Chondroitin Sulfate Antigens in Early Chick Pituitary and Thyroid
(East Carolina University, 2012)The chondroitin sulfate antigens d1C4 and TC2 have been hypothesized to play a role in cartilage differentiation in the limb and early morphogenesis of the heart in chick embryos. The antibody d1C4 recognizes a native ... -
A Study of the Abundance, Distribution, and Grazing Effects of Zooplankton in the Chlorophyll Maximum (CMAX) of the Neuse River Estuary, North Carolina
(East Carolina University, 2012)Phytoplankton tend to accumulate in distinct zones referred to as chlorophyll maxima, or CMAX. A pronounced CMAX occurs in the Neuse River Estuary (NRE), North Carolina, where as much as over 60% of the estuary's phytoplankton ... -
Targeting aberrant signaling in the EGFR1/HER2/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway : Novel therapeutic interventions in breast cancer
(East Carolina University, 2015)Breast cancer is attributed to being the second most deadly cancer in American women. Approximately 1 in 8 women will be diagnosed with breast cancer during her lifetime, and prognosis is dependent upon the genetic make-up ... -
The Effects Of Environmental Variation On Individual Variation
(East Carolina University, 2015)Despite general consensus among ecologists that variation is ubiquitous and important in nature, ecological experiments have historically focused on changes in mean response assuming a constant environment and interchangeable ... -
The therapeutic potential of Rho GTPase intervention
(East Carolina University, 2013)Small GTPases of the Rho family are well established regulators of critical cellular functions including cytoskeletal remodeling, motility, vesicle trafficking and cell cycle control. Additionally, aberrant signaling ... -
TOXICITY OF METAL OXIDE NANOPARTICLES TO CAENORHABDITIS ELEGANS
(East Carolina University, 2012)The increase in manufacturing and use of nanoparticles is expected to elevate levels of exposure to humans and other organisms. Presently, there is little understanding of the potential toxic effects of nanoparticle exposure. ... -
Tumor Growth Induces Oxidative Clustered DNA Lesions Damage in Distant Mouse Tissue in vivo
(East Carolina University, 2010)Our goal was to ascertain if DNA damage induced by oxidative stress is capable of being exploited as a precancerous or cancer biomarker. The specific DNA damage that we assessed was oxidatively induced non-DSB clustered ... -
Universal Design for Learning, the Library, and STEM: Common Cause, Uncommon Ground
(2013-07-01)In summer 2012, the Science Librarian and Instructional Design Librarian at Joyner Library, East Carolina University, came together to design a series of interactive tutorials to assist with questions related to an assignment ... -
USE OF GENETIC TECHNIQUES TO IDENTIFY THE DIET OF COWNOSE RAYS, RHINOPTERA BONASUS, IN NORTH CAROLINA AND VIRGINIA : AN ANALYSIS OF SHELLFISH PREY ITEMS
(East Carolina University, 2013)Cownose rays, Rhinoptera bonasus, are considered voracious predators on mollusks and have been implicated in the consumption of commercially important species of shellfish on the East Coast. Digestive tracts of the 32 ... -
USING LASER CAPTURE MICRODISSECTION (LCM) TO EXAMINE MADS-BOX GENE EXPRESSION IN THE UPPER AND LOWER FLORAL MERISTEMS OF MAIZE
(East Carolina University, 2013)MADS-box transcription factors are important regulators of flower development in all flowering plants. In the grasses, flowers (called florets) are contained in spikelets. Maize spikelets contain two florets (the upper and ... -
Using student motivation to design groups in a non-majors biology course for team-based collaborative learning : Impacts on knowledge, views, attitudes, and perceptions
(East Carolina University, 2014)The importance of student motivation and its connection to other learning variables (i.e., attitudes, knowledge, persistence, attendance) is well established. Collaborative work at the undergraduate level has been recognized ... -
VALIDATION OF CANDIDATE GENES IN RESPONSE TO VERSICAN MANIPULATION IN DEVELOPING SYNOVIAL JOINTS
(East Carolina University, 2012)Little is understood about the complex process of synovial joint formation in early limb development. It has been shown that versican is highly expressed in the extracellular matrix of these joints (Snow et al., 2005; ...