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Now showing items 2204-2223 of 10619
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Cyberloafing: A Study Of Personality Factors And Organizational Commitment As Predictor Variables Of Cyberloafing And Perceived Organizational Acceptance
(East Carolina University, 2015)The purpose of this study was to investigate the relationship between personality and organizational commitment with cyberloafing. Results indicate that all personality factors (conscientiousness, extraversion, agreeableness, ... -
A CYCLE OF CONTROL : WOMEN'S IDENTITY LOSS THROUGH COLONIALISM IN THE CARIBBEAN AND AFRICA
(East Carolina University, 2013)Through analysis of Purple Hibiscus by Chimamanda Ngozi Adichie, The Autobiography of My Mother by Jamaica Kincaid, and Beka Lamb by Zee Edgell this thesis explores women's loss of identity through colonialism and ways in ... -
Cyclic Deposition of Neogene Phosphorites in the Aurora Area, North Carolina, and their Possible Relationship to Global Sea-Level Fluctuations
(1982)The Neogene phosphorites in the Aurora Area occur within the Miocene Pungo River Formation (units A, B, C, and D) and the Pliocene Yorktown Formation (lower and upper units). These units are characterized by the following ... -
The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through anti-proliferative and pro-apoptotic effects
(East Carolina University, 2009-06)Guanosine-specific cyclic nucleotide signaling is suggested to serve protective actions in the vasculature; however, the influence of selective pharmacologic modulation of cyclic guanosine monophosphate (GMP)-synthesizing ... -
The cyclic-di-GMP signaling pathway in the Lyme disease spirochete,
(2014-05)In nature, the Lyme disease spirochete Borrelia burgdorferi cycles between the unrelated environments of the Ixodes tick vector and mammalian host. In order to survive transmission between hosts, B. burgdorferi must be ... -
The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi
(2014-05-01)In nature, the Lyme disease spirochete Borrelia burgdorferi cycles between the unrelated environments of the Ixodes tick vector and mammalian host. In order to survive transmission between hosts, B. burgdorferi must be ... -
Cystic Fibrosis Virtual Patient Advocacy
(2021-07-27)Cystic Fibrosis is a rare life-limiting genetic disorder that affects 30,000 people in the United States. The CF population has seen an increase in their life expectancy as new research, therapies and technology has ... -
CYTOKINE-BASED FUSION PROTEINS FOR TREATMENT OF MULTIPLE SCLEROSIS
(2014-12-30)The present invention provides fusion proteins including an autoimmune antigen, an allergen antigen or an alloantigen, and an anti-inflammatory cytokine. Compositions and meth ods including the fusion proteins are also provided. -
Cytokine-Neuroantigen Fusion Proteins as a New Class of Tolerogenic, Therapeutic Vaccines for Treatment of Inflammatory Demyelinating Disease in Rodent Models of Multiple Sclerosis
(2012-08)Myelin-specific induction of tolerance represents a promising means to modify the course of autoimmune inflammatory demyelinating diseases such as multiple sclerosis (MS). Our laboratory has focused on a novel preclinical ... -
Cytokine-neuroantigen fusion proteins as a new class of tolerogenic, therapeutic vaccines for treatment of inflammatory demyelinating disease in rodent models of multiple sclerosis
(2012-08-20)Myelin-specific induction of tolerance represents a promising means to modify the course of autoimmune inflammatory demyelinating diseases such as multiple sclerosis (MS). Our laboratory has focused on a novel preclinical ... -
Cytokines and neuroantigens for treatment of immune disorders
(2017-05-10)The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. ... -
Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
(2015-01)Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited colony ... -
Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
(2014)Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited ...