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Now showing items 4696-4715 of 10620
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Identification of Damaged DNA Adducts from Exposure to Benzo[a]pyrene in the TP53 Gene
(2015)Benzo[a]pyrene is a carcinogen associated with tobacco smoke that can damage DNA after it is metabolized into highly reactive forms. Identifying the resulting DNA adducts can give greater insight into the mutations that ... -
Identification of E2F1 as a positive transcriptional regulator for delta-catenin
(East Carolina University, 2008-05-02)Delta-Catenin is upregulated in human carcinomas. However, little is known about the potential transcriptional factors that regulate delta-catenin expression in cancer. Using a human delta-catenin reporter system, we have ... -
Identification of Extracellular d-Catenin Accumulation for Prostate Cancer Detection
(East Carolina University, 2009-03-01)BACKGROUND—Prostate cancer is the second leading cause of cancer death in men, and early detection is essential to reduce mortality and increase survival. δ-Catenin is a unique β-catenin superfamily protein primarily ... -
Identification of Factors Associated with the Development and Decay of Heterologous Tolerance to Morphine in the Guinea Pig
(East Carolina University, 2016-05-03)It is believed that the heterologous tolerance that develops upon chronic exposure to morphine is the result of adaptive changes in the cellular signaling pathways associated with the [mu] opioid receptor. Proposed adaptive ... -
IDENTIFICATION OF FACTORS THAT CONTRIBUTE TO AN INCREASE IN LIFEGUARD COMPLACENCY
(East Carolina University, 2011)The purpose of this thesis was to identify factors that predict lifeguard complacency in an effort to increase overall vigilance while lifeguarding. Three research questions were explored: (a) what factors contribute to ... -
Identification of galectin-1 as a marker for claudin-low breast cancer and implications for tumor progression
(East Carolina University, 2024-01-04)Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Patients with TNBC have a high rate of metastasis and mortality due to the lack of targeted therapies and resistance to chemotherapy. This ... -
IDENTIFICATION OF GEOCHEMICAL TRACERS WITHIN BIOMINERALS OF JUVENILE AND LARVAL MERCENARIA MERCENARIA : IMPLICATIONS FOR MODELING LARVAL DISPERSAL
(East Carolina University, 2013)This study was designed to investigate the application of geochemical signals within biominerals to identify site fidelity and natal origin of the commercially valuable bivalve Mercenaria mercenaria. My first study ... -
IDENTIFICATION OF IRON-OXIDIZING BACTERIA ON STEEL STRUCTURES IN FRESHWATER ENVIRONMENTS
(East Carolina University, 2023-04-26)Microorganisms found on steel structures within aquatic systems impact the integrity of the structures and environmental factors surrounding them. Iron-oxidizing bacteria (FeOB) in particular, can cause damage and corrosion ... -
IDENTIFICATION OF NOVEL CYTOTOXIC PROSTAGLANDIN METABOLITES PRODUCED IN ARACHIDONOYL ETHANOLAMIDE-TREATED TUMOREGENIC KERATINOCYTES
(East Carolina University, 2012)Arachidonoyl ethanolamide (AEA) induces apoptosis in mouse tumorigenic keratinocytes (JWF-2 cells). Our previous data show that AEA is metabolized by COX-2 to pro-apoptotic J-series prostaglandins. COX-2 is an enzyme that ... -
Identification of Residual Neuromuscular Blockade in Post-Surgical Patients
(2017-11-19)Background: Many surgical procedures require administration of nondepolarizing neuromuscular blocking (NDNMB) agents. NDNMBs are typically reversed when surgery ends, allowing function to be restored. With more precise ... -
Identification of Stress in Latino Families who have Young Exceptional Children
(East Carolina University, 2014)The Latino population in the US is growing and there are many stressors that can accompany life in a new country; much more so when a family has a child with special needs. The aim of the present study is to explore the ... -
Identification of the Cu(II) Coordinating Residues in the Prion Protein by Metal-Catalyzed Oxidation Mass Spectrometry: Evidence for Multiple Isomers at Low Cu(II) Loadings
(East Carolina University, 2008-09-02)While the Cu(II) binding sites of the prion protein have been well studied under Cu-saturation conditions, the identity of the residues involved in coordinating Cu(II) at low stoichiometries and the order in which the ... -
Identification of Vape Shops in Two North Carolina Counties: An Approach for States without Retailer Licensing
(2016-10-27)Stores that sell electronic nicotine delivery systems (ENDS) as their primary product are a new phenomenon and often termed “vape shops”. While vape shops are now regulated by state and federal agencies, not all states ... -
Identification, Characterization, and Abiotic Stress Analysis of microRNAs in Nicotiana tabacum
(East Carolina University, 2010)microRNAs (miRNAs) are non-coding RNAs with short sequences that negatively regulate gene expression at the post-transcriptional levels by either binding to mRNAs for degradation, or by inhibiting protein translation. ... -
Identification, characterization, and gene expression analysis of nucleotide binding site (NB)-type resistance gene homologues in switchgrass
(2016-11-08)Abstract Background Switchgrass (Panicum virgatum L.) is a warm-season perennial grass that can be used as a second generation bioenergy crop. However, foliar fungal ... -
Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor
(East Carolina University, 2003-03-04)Recently we discovered a previously uncharacterized gene with the characteristics of a membrane progestin receptor (mPR) in a fish model, spotted seatrout. Here, we report the identification, cloning, and characteristics ... -
Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus)
(East Carolina University, 2006-02-04)Background beta-defensins are small cationic peptides that exhibit broad spectrum antimicrobial properties. The majority of beta-defensins identified in humans are predominantly expressed in the male reproductive tract ...