Browsing by Author "Anderson, Eric"
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A QUALITATIVE STUDY OF MICROBES IN SERPENTINITE-HOSTED SUBSURFACE ENVIRONMENTS
Blackburn, Joe W. (East Carolina University, 1/13/16)Over the last two decades, serpentinizing environments have been studied with regards to the biogeochemistry of these habitats, but significantly less is known about the microbiology within these environments. Serpentinization ... -
An Ongoing Study of Simulating Life on Mars through Microbes Isolated from an Ophiolite Deposit
Moss, Nona Katherine (East Carolina University, 2022-05-04)This work aims to determine the properties of unknown microbial isolates found in rock cores estimated to be six million years old that have similar geological conditions to those predicted for Mars. The rock core was ... -
The AraC-Like Transcriptional Regulator DhbR Is Required for Maximum Expression of the 2,3-Dihydroxybenzoic Acid Biosynthesis Genes in Brucella abortus 2308 in Response to Iron Deprivation
Anderson, Eric; Paulley, James T.; Roop II, R. Martin (East Carolina University, 2008-03)Phenotypic evaluation of isogenic mutants derived from Brucella abortus 2308 indicates that the AlcR homolog DhbR (2,3-dihydroxybenzoic acid [2,3-DHBA] biosynthesis regulator) modulates the expression of the genes involved ... -
Determining the Chemical Structure of Brucebactin: The Sole Complex Siderophore Utilized by the Pathogenic Bacterium Brucella Abortus
Atkinson, Xavier J. (East Carolina University, 1/13/16)Brucellosis is a zoonotic bacterial disease that affects many around the world. There are over half a million new cases each year and prevalence rates in some areas of the world exceed 10 new cases per 100,000 in the ... -
EXPRESSION AND PURIFICATION OF THE REGULATORY DOMAIN OF HUMAN CARDIAC TROPONIN C (HCTNC): A PROTEIN METHOD OPTIMIZATION STUDY
Oliveira, Luis Felipe (East Carolina University, 2023-04-26)The purpose of this experimentation was to optimize the purification methodology for Human Cardiac Troponin C (HcTnC). This was done by replacing the old methodology of the size exclusion column and ion exchange column, ... -
Genetic regulation of maize floral development - insights from the transcriptome and translatome
Yang, Hailong (East Carolina University, 2022-06-24)Flowers are produced by floral meristems, groups of stem cells that give rise to floral organs. In grasses, including the major cereal crops, flowers (florets) are contained in spikelets, which contain one to many florets, ... -
Identification of a Potential RNAzyme in Brucella abortus with Heme-Dependent Peroxidase Activity
Chapman, Dalton L (East Carolina University, 2020-11-19)Bovine brucellosis is of significant concern to the U.S. cattle industry and has not been controlled by vaccination in some areas of the world. The inability to control this pathogen is currently a serious public health ... -
Investigating the Relationship Between Zetaproteobacteria and Cyanobacteria and its Implications for the Geological Record
Chamberlain, Michelle (East Carolina University, 2022-07-14)Banded Iron Formations (BIFs) are geological relics of the ancient oceans that were partially formed by microorganisms. This includes oxygenic phototrophs and iron-oxidizing bacteria (FeOB) whose relative contributions are ... -
Investigating the Structural and Functional Roles of Conserved Cysteine Residues in Arabidopsis thaliana Fatty-Acid Desaturase 2
Novotny, Lauren (East Carolina University, 2022-12-06)Plant-generated unsaturated fatty acids (UFAs) and polyunsaturated fatty acids (PUFAs) are vital to a plant's growth and survival through maintenance of plasma membrane fluidity and integrity, in addition to the various ... -
The Manganese Transporter MntH Is a Critical Virulence Determinant for Brucella abortus 2308 in Experimentally Infected Mice
Anderson, Eric; Paulley, James T.; Gaines, Jennifer M.; Valderas, Michelle W.; Martin, Daniel W.; Menscher, Evan A.; Brown, Timothy D.; Burns, Colin Sanderson; Roop II, R. Martin (East Carolina University, 2009-08)The gene designated BAB1_1460 in the Brucella abortus 2308 genome sequence is predicted to encode the manganese transporter MntH. Phenotypic analysis of an isogenic mntH mutant indicates that MntH is the sole high-affinity ... -
Purifying Scorpion Antarease from E. coli
Hudson, Victoria Elizabeth (East Carolina University, 2018-05-03)Vesicular trafficking is a system of intracellular transport that allows for the distribution and secretion of molecules. In the pancreas, normal secretory processes have been found to be interrupted by Antarease, a ... -
Square Wave Voltammetry Detection and CD Spectroscopy Structural Characterization of 5- Methyl Cytosine-Containing Oligomeric DNA Sequences
Preston, Victoria G (East Carolina University, 2023-01-04)DNA methylation, primarily at the 5-carbon in cytosine (5-methyl cytosine) plays a significant role in key processes and functions of the body, such as development of the brain and in neuronal cell differentiation. Lack ... -
The Direct and Indirect Impact of Sucralose on Immune Function
Gray, Taylor Jefferson (East Carolina University, 2017-12-18)1, 6-dichloro-1, 6- dideoxy-[beta]-D-fructofuranosyl-4-chloro-4-deoxy -[alpha]-D-galactopyranoside, or Sucralose, is a highly popular NAS (Non-caloric artificial sweetener) used by millions across the globe for sweetening ... -
THE EFFECT OF SOCIAL EXPERIENCE ON THE SYNERGISTIC NEUROMODULATION OF MOTOR CIRCUITS
Clements, Katie (East Carolina University, 2022-07-15)Forming social groups is a critical adaptive strategy for the survival of many animal species, where conflict between members can result in dominance relationships. Dominance relationships are often formed through aggressive ... -
The Effects of the Unnatural Amino Acid TTO- 53 on the Biofilm of Staphylococcus aureus
Norman, Mina (East Carolina University, 2023-07-18)There are over 30 different species of staphylococci and many cause infection that can lead to hospitalization or death. The member most associated with chronic infection is Staphylococcus aureus. Staphylococcus aureus is ... -
The small GTPase Ran and β-importins Tnpo-SR and Cadmus promote ovarian cyst formation in Drosophila
Beachum, Allison N (East Carolina University, 2021-06-14)Germ cells follow a precise and coordinated molecular timeline to produce a viable oocyte. While undergoing mitotic expansion via incomplete cytokinesis, cysts of undifferentiated cells form and remain interconnected prior ...