Browsing by Author "Bergamo, Paola"
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Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia
Iacovelli, Stefano; Ricciardi, Maria Rosaria; Allegretti, Matteo; Mirabilii, Simone; Licchetta, Roberto; Bergamo, Paola; Rinaldo, Cinzia; Zeuner, Ann; Foá , Robin; Milella, Michele; McCubrey, James A.; Martelli, Alberto M.; Tafuri, Agostino (2015-10)Several chemo-resistance mechanisms including the Bcl-2 protein family overexpression and constitutive activation of the PI3K/Akt/mTOR signaling have been documented in acute lymphoblastic leukemia (ALL), encouraging ... -
MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex
Konopleva, M; Milella, M; Ruvolo, P; Watts, JC; Ricciardi, MR; Korchin, B; McQueen, T; Bornmann, W; Tsao, T; Bergamo, Paola; Mak, DH; Chen, W; McCubrey, J; Tafuri, A; Andreeff, M (2012-04)Recently, strategies for acute myeloid leukemia (AML) therapy have been developed that target anti-apoptotic BCL2 family members using BH3-mimetic drugs such as ABT-737. Though effective against BCL2 and [BCL-X.sub.L], ...