Browsing by Author "Brault, Jeffrey J."
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A Smad3/FoxO3 Transcriptional Relationship in the Regulation of Vascular Growth
Francisco, Jake (East Carolina University, 2019-06-05)Cardiovascular disease (CVD) is a multi-faceted pathological condition that continually ranks as the number one cause of morbidity and mortality in the United States and worldwide. Unfortunately, despite extensive basic ... -
AMP Deaminase 3 in Skeletal Muscle Atrophy: Regulation of Protein Degradation and Contractile Performance
Davis, Patrick R. (East Carolina University, 2015-11-23)Skeletal muscle atrophy is characterized by depressed cellular energetics, increased rates of protein degradation, contractile deficits and loss of muscle mass. A potential regulator of these impairments is the metabolic ... -
AMP Deaminase 3 knockout mice and loss of mitochondrial proteins and enzyme activity during denervation atrophy
Verhoeven, Nicolas (East Carolina University, 2018-07-17)Muscle atrophy leads to decrements in muscle function, partly attributable to decreased mitochondrial content. One controller of mitochondrial content is AMP-activated protein kinase (AMPK), which when bound by AMP activates ... -
AMP Deaminase 3 overexpression regulates cellular energetics and signaling for PGC-1α activation.
Miller, Spencer (East Carolina University, 2017-06-02)Skeletal muscles undergoing atrophy have decreased [ATP], PGC-1[alpha] expression, and mitochondrial content. This combination of findings is unexpected because decreased [ATP] is often associated with greater [AMP] and ... -
Constitutively Active CaMKKa Stimulates Skeletal Muscle Glucose Uptake in InsulinResistant Mice In Vivo
Hinkley, J. Matthew; Ferey, Jeremie L.; Brault, Jeffrey J.; Smith, Cheryl A.S.; Gilliam, Laura A.A.; Witczak, Carol A. (2014) -
Constitutively Active CaMKKα Stimulates Skeletal Muscle Glucose Uptake in Insulin-Resistant Mice In Vivo
Hinkley, J. Matthew; Ferey, Jeremie L.; Brault, Jeffrey J.; Smith, Cheryl A. S.; Gilliam, Laura A. A.; Witczak, Carol A. (2014-01) -
Diminished Force Production and Mitochondrial Respiratory Deficits are Strain-Dependent Myopathies of Subacute Limb Ischemia
McClung, Joseph; Schmidt, Cameron A.; Ryan, Terence E.; Lin, Chien-Te; Inigo, Melissa M. R; Green, Tom D.; Brault, Jeffrey J.; Spangenburg, Espen E. (2017-05-01) -
Diminished Force Production and Mitochondrial Respiratory Deficits are Strain-Dependent Myopathies of Subacute Limb Ischemia
Spangenburg, Espen; Schmidt, Cameron A.; Ryan, Terence E.; Lin, Chien-Te; Inigo, Melissa M.R.; Green, Tom D.; Brault, Jeffrey J.; McClung, Joseph M. (2017-05-01) -
Effects of Fasting on Isolated Murine Skeletal Muscle Contractile Function During Acute Hypoxia
Spangenburg, Espen; Schmidt, Cameron A.; Goldberg, Emma J.; Green, Tom D.; Karnekar, Reema R.; Brault, Jeffrey J.; Amorese, Adam J.; Yamaguchi, Dean J.; McClung, Joseph M. (2020-04-23) -
Effects of Fasting on Isolated Murine Skeletal Muscle Contractile Function During Acute Hypoxia
McClung, Joseph M.; Schmidt, Cameron A.; Goldberg, Emma J.; Green, Tom D.; Karnekar, Reema R.; Brault, Jeffrey J.; Amorese, Adam J.; Spangenburg, Espen E. (2020-04-23) -
Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle
Bollinger, Lance M. (East Carolina University, 2013)Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle by Lance M. Bollinger November, 2013 Director of Thesis/Dissertation: Jeffrey J. Brault Major Department: Kinesiology ... -
High-Fat Diet Induced Obesity Increases Serum Myostatin, but Does Not Accelerate Skeletal Muscle Atrophy
Roseno, Steven L. (East Carolina University, 2013)Myostatin is a potent negative regulator of muscle mass, i.e. high levels of myostatin induce loss of muscle. Surprisingly, severely obese humans and obese mice have elevated levels of serum myostatin, but the role of ... -
Increased Degradation of Adenosine Monophosphate as a Regulator of Maximal Mitochondrial Respiration
Springer, Catherine B (East Carolina University, 2019-07-02)Atrophied skeletal muscle have enhanced fatigability due at least in part to a reduction of mitochondria content. Mitochondrial biogenesis is regulated by the transcriptional coactivator PGC-1 alpha, which in turn is ... -
Insulin Resistance Is Not Sustained Following Denervation in Glycolytic Skeletal Muscle
McMillin, Shawna L.; Stanley, Erin C.; Weyrauch, Luke A.; Brault, Jeffrey J.; Kahn, Barbara B.; Witczak, Carol A. (2021-05-06) -
Mouse Strain Dependent Differences in Muscle Fiber Type, Fiber Area, and Blood Perfusion in Response to Denervation Atrophy
Hakimi, Javid (East Carolina University, 1/13/16)Skeletal muscle atrophy caused by denervation is a serious consequence of neuropathic disease, especially diabetes. However, the only proven treatment for muscle atrophy is exercise, which can be difficult or impossible ... -
Peroxisomal gene and protein expression increase in response to a high-lipid challenge in human skeletal muscle
Huang, Tai-Yu; Zheng, Donghai; Hickner, Robert C.; Brault, Jeffrey J.; Cortright, Ronald N. (2020-04-21)Peroxisomes are essential for lipid metabolism and disruption of liver peroxisomal function results in neonatal death. Little is known about how peroxisomal content and activity respond to changes in the lipid environment ... -
Short-term, high-fat diet accelerates disuse atrophy and protein degradation in a muscle-specific manner in mice
Roseno, Steven L.; Davis, Patrick R.; Bollinger, Lance M.; Powell, Jonathan J. S.; Witczak, Carol A.; Brault, Jeffrey J. (2015-11-04)Background: A short-term high-fat diet impairs mitochondrial function and the ability of skeletal muscle to respond to growth stimuli, but it is unknown whether such a diet alters the ability to respond to atrophy signals. ... -
Short-term, high-fat diet accelerates disuse atrophy and protein degradation in a muscle-specific manner in mice
Roseno, Steven L.; Davis, Patrick R.; Bollinger, Lance M.; Powell, Jonathan J. S.; Witczak, Carol A.; Brault, Jeffrey J. (2015-11) -
THE EFFECT OF AMP DEAMINASE 3 DEFICIENCY ON POST-MYOCARDIAL INFARCT FUNCTIONAL AND HISTOLOGICAL OUTCOMES IN MICE
Clunan, Marie C. (East Carolina University, 2019-07-17)PURPOSE: Humans deficient in the metabolic enzyme AMP deaminase 3 have improved survival and clinical outcomes in cases of revascularization, myocardial infarction, and/or heart failure. Because of the nature of this ...