Browsing by Author "Chen, Yan-Hua"
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The claudin family of proteins in human malignancy: A clinical perspective
Ding, Lei; Lu, Zhe; Lu, Qun; Chen, Yan-Hua (2013-10-07)Tight junctions, or zonula occludens, are the most apical component of the junctional complex and provide one form of cell–cell adhesion in epithelial and endothelial cells. Nearly 90% of malignant tumors are derived from ... -
The claudin family of proteins in human malignancy: a clinical perspective
Ding, Lei; Lu, Zhe; Lu, Qun; Chen, Yan-Hua (2013) -
Claudin-7 increases chemosensitivity to cisplatin in human NCI-H522 lung cancer cells
Hoggard, John Elliott (East Carolina University, 2010)Lung cancer is a leading cause of cancer death for both men and women worldwide. The 5-year survival rate for lung cancer is only 15%, and it accounts for approximately 1.4 million deaths every year. Recently, it has ... -
Claudin-7 Modulates Cl− and Na+ Homeostasis and WNK4 Expression in Renal Collecting Duct Cells
Fan, Junming; Tatum, Rodney; Hoggard, John; Chen, Yan-Hua (2019-07-30)Claudin-7 knockout (CLDN7−/−) mice display renal salt wasting and dehydration phenotypes. To address the role of CLDN7 in kidneys, we established collecting duct (CD) cell lines from CLDN7+/+ and CLDN7−/− mouse kidneys. ... -
Claudins in intestines
Lu, Zhe; Ding, Lei; Lu, Qun; Chen, Yan-Hua (2013-07) -
Claudin‑7 modulates cell‑matrix adhesion that controls cell migration, invasion and attachment of human HCC827 lung cancer cells
KIM, DO HYUNG; LU, QUN; Chen, Yan-Hua (2018-12-31)Claudins are a family of tight junction proteins, and serve important roles in epithelial barrier, selective ion transports and cancer metastasis. Although the exact role of claudin-7 in human lung cancer has not been ... -
Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation
Boykin, Christi; Zhang, G.; Chen, Yan-Hua; Zhang, R-W; Fan, X-E; Yang, W-M; Lu, Q. (2011-03) -
delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles
Zeng, Yan; Abdallah, Agustin; Lu, Jian-Ping; Wang, Tao; Chen, Yan-Hua; Terrian, David M.; Kim, Kwonseop; Lu, Qun (East Carolina University, 2009-03-10)Background: delta-Catenin is a unique member of delta-catenin/armadillo domain superfamily proteins and its primary expression is restricted to the brain. However, delta-catenin is upregulated in human prostatic adenocarcinomas, ... -
[Delta]-catenin: implications in prostate cancer progression
Nopparat, Jongdee (East Carolina University, 2014)Prostate cancer (PCa) is the most commonly diagnosed cancer and the second most common cause of cancer death among men in the US. Due to the advances in research, the ability to detect and cure PCa has improved and led to ... -
Functions of claudin-7 in human lung cancer
Lu, Zhe (East Carolina University, 2012)Lung cancer is the second most common cancer and the most common cause of cancer-related death in both men and women in the United States with a very poor overall 5-year survival rate. Nearly 95% of the lung cancer originates ... -
FUNCTIONS OF CLAUDIN-7 IN THE SELF-RENEWAL OF INTESTINAL EPITHELIUM
Xing, Tiaosi (East Carolina University, 8/5/2020)Tight junctions (TJ) are located at the most apical region of the junctional complex and contain many integral membrane proteins. Claudin 7 (Cldn7) is a TJ membrane protein located at the apical TJ and basolateral side of ... -
Human homolog of airy and nhancer of plit 1, Hes1, negatively regulates δ-catenin () expression in cooperation with E2F1 in prostate cancer
Lu, Jian-Ping; Zhang, Jiao; Kim, Kwonseop; Case, Thomas C.; Matusik, Robert J.; Chen, Yan-Hua; Wolfe, Michael; Nopparat, Jongdee; Lu, Qun (2010) -
Identification of Extracellular d-Catenin Accumulation for Prostate Cancer Detection
Lu, Qun; Zhang, Jiao; Allison, Ron R.; Gay, Hiram A.; Yang, Wan-Xi; Bhowmick, Neil; Frelix, Gloria; Shapell, Scott; Chen, Yan-Hua (East Carolina University, 2009-03-01)BACKGROUND—Prostate cancer is the second leading cause of cancer death in men, and early detection is essential to reduce mortality and increase survival. δ-Catenin is a unique β-catenin superfamily protein primarily ... -
Increased nucleotide polymorphic changes in the 5'-untranslated region of δ-catenin (CTNND2) gene in prostate cancer
Wang, Tao; Chen, Yan-Hua; Hong, Heng; Zeng, Yan; Zhang, Jiao; Lu, Jian-Ping; Jeansonne, Beverly; Lu, Qun (East Carolina University, 2009-01)Cancer pathogenesis involves multiple genetic and epigenetic alterations, which result in oncogenic changes in gene expression. δ-Catenin (CTNND2) is overexpressed in cancer although the mechanisms of its upregulation are ... -
Investigating Non-Tight Junction Functions of Claudin-7: Regulating Large Intestine Stem Cell Functions and Niche Maintenance, and Junctional Protein Nanoarchitecture
Naser, Amna (East Carolina University, 2022-12-12)Edit this abstract. -
Method of detecting cancer using delta-catenin
Lu, Qun; Chen, Yan-Hua (2008-11-04)The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from ... -
Necrotizing enterocolitis leads to disruption of tight junctions and increase in gut permeability in a mouse model
Ravisankar, Srikanth; Tatum, Rodney; Garg, Parvesh M; Herco, Maja; Shekhawat, Prem S.; Chen, Yan-Hua (2018-11-27)Background: Necrotizing enterocolitis (NEC) is a leading cause of death in preterm infants. Neonates weighing <1500 grams are at the highest risk for acquiring NEC, with a prevalence of nearly 7-10%, mortality up to 30%, ... -
A non-tight junction function of claudin-7—Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment
Lu, Zhe; Kim, Do Hyung; Fan, Junming; Lu, Qun; Verbanac, Kathryn; Ding, Lei; Renegar, Randall; Chen, Yan-Hua (2015-06-17)Background Claudins are a family of tight junction (TJ) membrane proteins involved in a broad spectrum of human diseases including cancer. Claudin-7 is a unique TJ membrane protein in that it has a strong basolateral ... -
Nonreceptor Tyrosine Kinase c-Yes Interacts with Occludin during Tight Junction Formation in Canine Kidney Epithelial Cells
Chen, Yan-Hua; Lu, Qun; Goodenough, Daniel A.; Jeansonne, Beverly (East Carolina University, 2002-04)Occludin is an integral membrane protein that is tyrosine phosphorylated when localized at tight junctions. When Ca2 was depleted from the culture medium, occludin tyrosine phosphorylation was diminished from Madin-Darby ... -
Suppression of claudin-7 enhances human lung cancer cell survival
Jackson, Spencer Miller (East Carolina University, 2016-04-29)Claudin-7 belongs to a group of tight junction membrane proteins that play vital roles in many human diseases including human lung cancer. Lung cancer is noted to be the leading cause of cancer death for both men and women ...