Browsing by Author "Cistola, David"
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Compact NMR relaxometry of human blood and blood components
Cistola, David; Robinson, Michelle D. (2016-10)Nuclear magnetic resonance relaxometry is a uniquely practical and versatile implementation of NMR technology. Because it does not depend on chemical shift resolution, it can be performed using low- field compact instruments ... -
NMR method for monitoring changes in the core of lipoprotein particles in metabolism and disease
Cistola, David; Robinson, Michelle (2017-01-14)A method is disclosed for measuring the properties of protein and lipoprotein elements in a sample. The method includes the of placing a small volume of a sample into a NMR instrument tuned to measure a particular nucleus, ... -
Novel diagnostic and analytical applications of benchtop time-domain NMR.
Robinson, Michelle Denise (East Carolina University, 2015)High-resolution nuclear magnetic resonance (NMR) spectroscopy is a powerful technique, yet practical application outside of the research laboratory has been limited due to the high cost and complexity of the instrumentation. ... -
The RXR-alpha C-terminus T462 is a NMR sensor for coactivator peptide binding
Lu, Jianyun; Chen, Minghe; DeKoster, Gregory T.; Cistola, David; Li, Ellen (East Carolina University, 2008-02-22)The C-terminal activation function-2 (AF-2) helix plays a crucial role in retinoid X receptor alpha (RXRα)-mediated gene expression. Here, we report a nuclear magnetic resonance (NMR) study of the RXRα ligand-binding domain ... -
Water T2 as an early, global and practical biomarker for metabolic syndrome: an observational cross-sectional study
Robinson, Michelle D.; Mishra, Ina; Deodhar, Sneha; Patel, Vipulkumar; Gordon, Katrina V.; Vintimilla, Raul; Brown, Kim; Johnson, Leigh; O’Bryant, Sid; Cistola, David (2017-12-19)Background: Metabolic syndrome (MetS) is a highly prevalent condition that identifies individuals at risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease. Prevention of these diseases relies on ...