Browsing by Author "Clemens, Stefan"
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CENTRAL SENSORIMOTOR CHANGES DUE TO PERIPHERAL NERVE INJURY: ROLE OF DOPAMINERGICS AND OPIOIDS
Schaub, Mandee Kate (East Carolina University, 2022-04-28)Chronic neuropathic pain (CNP) is a disease typically resulting from injury to the central or peripheral nervous system. CNP has a prevalence of 12-15% in the population, but current treatments are not highly efficacious ... -
CHANGES IN INSULIN RESISTANCE ASSOCIATED WITH CHRONIC AIRWAY ALLERGEN EXPOSURES IN A SPONTANEOUSLY OBESE, NONHUMAN PRIMATE MODEL OF ALLERGIC ASTHMA
Woolard, Hannah G (East Carolina University, 2021-08-16)Obesity and asthma are two major well-recognized and interconnected major health problems, but the mechanisms that underlie the association of these two chronic inflammatory disease states are still unknown. Novel insights ... -
Consensus Guidelines on the Construct Validity of Rodent Models of Restless Legs Syndrome
Clemens, Stefan; Salminen, Aaro V. (2022) -
Differential aging-related changes of D1, D2, and D3 dopamine receptor expression in the striatum
Patel, Mukund (2013-05-03)Aging is associated with a decrease in motor function and a concomitant increase in muscle stiffness and tone. The striatum plays a critical role in the control of motor function, and it receives strong dopamine (DA) ... -
Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome
Meneely, Samantha; Dinkins, Mai-Lynne; Kassai, Miki; Lyu, Shangru; Liu, Yuning; Lin, Chien-Te; Brewer, Kori L.; Li, Yuqing; Clemens, Stefan (2018-09-04)Restless Legs Syndrome (RLS) is often and successfully treated with dopamine receptor agonists that target the inhibitory D3 receptor subtype, however there is no clinical evidence of a D3 receptor dysfunction in RLS ... -
Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord
Brewer, Kori L.; Baran, Christine A.; Whitfield, Brian R.; Jensen, A. Marley; Clemens, Stefan (2014-06)Abstract Dopamine (DA) modulates spinal reflexes, including nociceptive reflexes, in part via the D3 receptor subtype. We have previously shown that mice lacking the functional D3 receptor (D3KO) exhibit decreased paw ... -
The Dopamine D3 Receptor Knockout Mouse Mimics Aging-Related Changes in Autonomic Function and Cardiac Fibrosis
Johnson, Tracy L.; Tulis, David A.; Keeler, Benjamin E.; Virag, Jitka A.; Lust, Robert M.; Clemens, Stefan (2013-08-30)Blood pressure increases with age, and dysfunction of the dopamine D3 receptor has been implicated in the pathogenesis of hypertension. To evaluate the role of the D3 receptor in aging-related hypertension, we assessed ... -
Dopaminergic modulation of the autonomic nervous system: in vitro and in vivo evidence from the mouse
Johnson, Tracy L. (East Carolina University, 2012)Central nervous system (CNS) function depends on both the connections between the underlying neurons and neural circuits and their activity. Neuronal activity in turn can be classified as neurotransmission and neuromodulation, ... -
Examination and Comparison of Theta Band Connectivity in Left- and Right-Hand Dominant Individuals throughout a Motor Skill Acquisition
McDonnell, Jessica; Murray, Nicholas P.; Ahn, S.; Clemens, Stefan; Everhart, D. Erik; Mizelle, J. Chris (2021-04-21) -
Pivotal Role of Adenosine Neurotransmission in Restless Legs Syndrome
Ferré, Sergi; Quiroz, César; Guitart, Xavier; Rea, William; Seyedian, Arta; Moreno, Estefanía; Casadó-Anguera, Verònica; Díaz-Ríos, Manuel; Casadó, Vicent; Clemens, Stefan; Allen, Richard P.; Earley, Christopher J.; García-Borreguero, Diego (2018-01-08)The symptomatology of Restless Legs Syndrome (RLS) includes periodic leg movements during sleep (PLMS), dysesthesias, and hyperarousal. Alterations in the dopaminergic system, a presynaptic hyperdopaminergic state, seem ... -
SPINAL CORD REFLEXES IN A BRAIN-IRON DEFICIENT MODEL OF RESTLESS LEGS SYNDROME: ROLE OF DOPAMINE AND ADENOSINE RECEPTORS
Woods, Sydney (East Carolina University, 2021-05-04)Restless Legs Syndrome (RLS) is a sensorimotor disorder that severely disrupts sleep. RLS patients regularly present with a condition known as Brain Iron Deficiency (BID), and BID is commonly associated with altered dopamine ... -
The Dopamine D3 Receptor Knockout Mouse Mimics Aging-Related Changes in Autonomic Function and Cardiac Fibrosis
Johnson, Tracy L.; Tulis, David A.; Keeler, Benjamin E.; Virag, Jitka A. I.; Lust, Robert M.; Clemens, Stefan (2013-)