Browsing by Author "Degnim, Amy"
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Aurora-A Mitotic Kinase Induces Endocrine Resistance through Down-Regulation of ERα Expression in Initially ERα+ Breast Cancer Cells
Opyrchal, Mateusz; Salisbury, Jeffrey L.; Zhang, Shuya; McCubrey, James A.; Hawse, John; Goetz, Matthew P.; Lomberk, Gwen A.; Haddad, Tufia; Degnim, Amy; Lange, Carol A.; Ingle, James N.; Galanis, Evanthia; D'Assoro, Antonino B. (2014)Development of endocrine resistance during tumor progression represents a major challenge in the management of estrogen receptor alpha (ERα) positive breast tumors and is an area under intense investigation. Although the ... -
Molecular targeting of the Aurora-A/SMAD5 oncogenic axis restores chemosensitivity in human breast cancer cells
Opyrchal, Mateusz; Gil, Malgorzata; Salisbury, Jeffrey L.; Goetz, Mathew P.; Suman, Vera; Degnim, Amy; McCubrey, James; Haddad, Tufia; Iankov, Ianko; Kurokawa, Chenye B.; Shumacher, Nicole; Ingle, James N.; Galanis, Evanthia; D’Assoro, Antonino B. (2017-09-01)Although the majority of breast cancers initially respond to the cytotoxic effects of chemotherapeutic agents, most breast cancer patients experience tumor relapse and ultimately die because of drug resistance. Breast ...