Browsing by Author "Ellis, Jessica M"
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Defining the role of acyl-CoA synthetase 6 on α-synucleinopathy
Smaltz, Amber (East Carolina University, 2022-07-19)Background: Neurodegenerative diseases known as [alpha]-synucleinopathies, most notably dementias and Parkinson's Disease (PD), are characterized by neuronal aggregation and accumulation of [alpha]-synuclein ([alpha]-syn) ... -
Discovering mechanisms during spermatogonial differentiation that prepare male germ cells for meiosis
Johnson, Taylor A (East Carolina University, 2022-12-05)Spermatogenesis, the male germ cell maturation process, allows men to become and remain fertile for decades. Male fertility relies on fate decisions of different types of spermatogonia – spermatogonial stem cells maintain ... -
HUMAN RNA METHYLTRANSFERASE METTL16 AFFECTS MULTIPLE CELL PROCESSES THROUGH DIFFERENTIAL FUNCTION OF ITS DOMAINS
Talic, Emily Satterwhite (East Carolina University, 2022-11-10)ABSTRACT In recent years, disease therapies have been developed to target specific RNA and protein expression changes in the affected cells/tissue. The RNA post-transcriptional modification, methyl-6-adenosine (m6A), has ...