Browsing by Author "Garrigues, Ryan J."
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Lipoproteome Screening of the Lyme Disease Agent Identifies Inhibitors of Antibody-Mediated Complement Killing
Garrigues, Ryan J.; Garcia, Brandon L.; et al (2022) -
Outer Surface Lipoproteins from the Lyme Sisease Spirochete Exploit the Molecular Switch Mechanism of the Complement Protease C1s
Garrigues, Ryan J.; Thomas, Sheila; Garcia, Brandon L.; Leong, John M. (2022-09-29) -
A Structural Basis for Inhibition of the Complement Initiator Protease C1r by Lyme Disease Spirochetes
Garrigues, Ryan J.; Garcia, Brandon L.; Pierce, Alexandra D. Powell; Hammel, Michal; Skare, Jon T. (2021-07-04) -
Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes
Xie, Jialei; Zhi, Hui; Garrigues, Ryan J.; Keightley, Andrew; Garcia, Brandon L.; Skare, Jon T. (2019-03-21)The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r. In this study we ...