Browsing by Author "Guo, Zhenhua"
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Comparative Genomics and Evolution of Proteins Associated with RNA Polymerase II C-Terminal Domain
Guo, Zhenhua; Stiller, John W. (2005-11)The C-terminal domain (CTD) of the largest subunit of RNA polymerase II provides an anchoring point for a wide variety of proteins involved in mRNA synthesis and processing. Most of what is known about CTD-protein interactions ... -
Comparative genomics of cyclin-dependent kinases suggest co-evolution of the RNAP II C-terminal domain and CTD-directed CDKs
Guo, Zhenhua; Stiller, John W. (East Carolina University, 2004-09-20)Background: Cyclin-dependent kinases (CDKs) are a large family of proteins that function in a variety of key regulatory pathways in eukaryotic cells, including control over the cell cycle and gene transcription. Among the ... -
Connecting Mutations of the RNA Polymerase II C-Terminal Domain to Complex Phenotypic Changes Using Combined Gene Expression and Network Analyses
Rogers, Carlyle; Guo, Zhenhua; Stiller, John W. (2010)The C-terminal domain (CTD) of the largest subunit in DNA-dependent RNA polymerase II (RNAP II) is essential for mRNA synthesis and processing, through coordination of an astounding array of protein-protein interactions. ...