Browsing by Author "Hager, Paul W."
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Cloning and Characterization of the Pseudomonas aeruginosa zwf Gene Encoding Glucose-6-Phosphate Dehydrogenase, an Enzyme Important in Resistance to Methyl Viologen (Paraquat)
Ma, Ju-Fang; Hager, Paul W.; Howell, Michael L.; Phibbs, Paul V.; Hassett, Daniel J. (East Carolina University, 1998-04)In this study, we cloned the Pseudomonas aeruginosa zwf gene, encoding glucose-6-phosphate dehydrogenase (G6PDH), an enzyme that catalyzes the NAD1- or NADP1-dependent conversion of glucose-6-phosphate to 6-phosphogluconate. ... -
Crc Is Involved in Catabolite Repression Control of the bkd Operons of Pseudomonas putida and Pseudomonas aeruginosa
Hester, Kathryn L.; Lehman, Jodi; Najar, Fares; Song, Lin; Roe, Bruce A.; MacGregor, Carolyn H.; Hager, Paul W.; Phibbs, Paul V. Jr; Sokatch, John R. (East Carolina University, 2000-02)Crc (catabolite repression control) protein of Pseudomonas aeruginosa has shown to be involved in carbon regulation of several pathways. In this study, the role of Crc in catabolite repression control has been studied in ... -
The Global Carbon Metabolism Regulator Crc Is a Component of a Signal Transduction Pathway Required for Biofilm Development by Pseudomonas aeruginosa
O'Toole, George A.; Gibbs, Karine A.; Hager, Paul W.; Phibbs, Paul V. Jr.; Kolter, Roberto (East Carolina University, 2000-01)The transition from a planktonic (free-swimming) existence to growth attached to a surface in a biofilm occurs in response to environmental factors, including the availability of nutrients. We show that the catabolite ... -
The nucleotide sequence of the Pseudomonas aeruginosa pyrE-crc-rph region and the purification of the crc gene product.
MacGregor, Carolyn H.; Arora, Shiwani K.; Hager, Paul W.; Dail, Mary Beth; Phibbs, Paul V. Jr. (East Carolina University, 1996-10)The gene (crc) responsible for catabolite repression control in Pseudomonas aeruginosa has been cloned and sequenced. Flanking the crc gene are genes encoding orotate phosphoribosyl transferase (pyrE) and RNase PH (rph). ... -
The Pseudomonas aeruginosa devB/SOL Homolog, pgl, Is a Member of the hex Regulon and Encodes 6-Phosphogluconolactonase
Hager, Paul W.; Calfee, M. Worth; Phibbs, Paul V. (East Carolina University, 2000-07)A cyclic version of the Entner-Doudoroff pathway is used by Pseudomonas aeruginosa to metabolize carbohydrates. Genes encoding the enzymes that catabolize intracellular glucose to pyruvate and glyceraldehyde 3- phosphate ... -
THE DEVELOPMENT OF BETA-ACTIN MUTANTS WITH ALTERED BINDING AFFINITES FOR ATP AND ADP
Kuyateh, Abu-Bakarr (East Carolina University, 2018-12-10)A number of neurodegenerative diseases are accompanied by the formation of cofilin-actin rods in neural cells. These rods can cause synaptic dysfunction and block transport within neurites. The overall goal of this project ...