Browsing by Author "Hughes, Robert M."
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Collective ERK/Akt Activity Waves Orchestrate Epithelial Homeostasis by Driving Apoptosis-Induced Survival
Hughes, Robert M.; Gagliardi, Paolo Armando; Dobrzyński, Maciej; Jacques, Marc-Antoine; Dessauges, Coralie; Ender, Pascal; Blum, Yannick; Cohen, Andrew R.; Pertz, Olivier (2021-06-21) -
CRY–BARs: Versatile Light-Gated Molecular Tools for the Remodeling of Membrane Architectures
Wurz, Anna I.; Hughes, Robert M.; Bunner, Wyatt P.; Szatmari, Erzsebet M. (2022-08-18) -
Imaging of morphological and biochemical hallmarks of apoptosis with optimized optogenetic tools
Godwin, Walton C.; Hoffmann, George F.; Gray, Taylor J.; Hughes, Robert M. (2019-10-03)Creation of optogenetic switches for specific activation of cell death pathways can provide insights into apoptosis and could also form a basis for noninvasive, next-generation therapeutic strategies. Previous work has ... -
protaTETHER - A Method for the Incorporation of Variable Linkers in Protein Fusions Reveals Impacts of Linker Flexibility in a PKAc-GFP Fusion Protein
Norris, Jessica L.; Hughes, Robert M. (2018-04-25)Protein fusions are of fundamental importance in the study of cellular biology and the elucidation of cell signaling pathways, and the importance of linkers for the proper function of protein fusions is well documented in ... -
protaTETHER – a method for the incorporation of variable linkers in protein fusions reveals impacts of linker flexibility in a PKAc‐GFP fusion protein
Norris, Jessica L.; Hughes, Robert M. (2018-03-14)Protein fusions are of fundamental importance in the study of cellular biology and the elucidation of cell signaling pathways, and the importance of linkers for the proper function of protein fusions is well documented in ... -
THE DEVELOPMENT OF BETA-ACTIN MUTANTS WITH ALTERED BINDING AFFINITES FOR ATP AND ADP
Kuyateh, Abu-Bakarr (East Carolina University, 2018-12-10)A number of neurodegenerative diseases are accompanied by the formation of cofilin-actin rods in neural cells. These rods can cause synaptic dysfunction and block transport within neurites. The overall goal of this project ... -
Transfection and Activation of CofActor, a Light and Stress Gated Optogenetic Tool, in Primary Hippocampal Neuron Cultures
Bunner, Wyatt P.; Dodson, Rachel; Szatmari, Erzsebet M.; Hughes, Robert M. (2021) -
Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers
Dasari, Anvesh K. R.; Hughes, Robert M.; Wi, Sungsool; Hung, Ivan; Gan, Zhehong; Kelly, Jeffrey W.; Lim, Kwang Hun (2019-01-10)Characterization of small oligomers formed at an early stage of amyloid formation is critical to understanding molecular mechanism of pathogenic aggregation process. Here we identifed and characterized cytotoxic oligomeric ...