Browsing by Author "Kane, Daniel A."

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  • Effects of Insulin Sensitivity Modulators on the Mitochondrial Fate of Oxygen in Skeletal Muscle 

    Kane, Daniel A. (East Carolina University, 2010)
    Increasingly, reactive oxygen species (ROS) are implicated in the development of insulin resistance. To test the hypothesis that modulators of insulin sensitivity (i.e., metformin, ovarian sex steroids and exercise training) ...

  • Metformin Improves Insulin Signaling in Obese Rats via Reduced IKK Action in a Fiber-Type Specific Manner 

    Bikman, Benjamin Thomas; Zheng, Donghai; Kane, Daniel A.; Anderson, Ethan; Woodlief, Tracey L.; Price, Jesse W.; Dohm, G. Lynis; Neufer, P. Darrell; Cortright, Ronald N. (2010)
    Metformin is a widely used insulin-sensitizing drug, though its mechanisms are not fully understood. Metformin has been shown to activate AMPK in skeletal muscle; however, its effects on the inhibitor of κB kinaseβ (IKKβ) ...

  • Methods for assessing mitochondrial function in diabetes 

    Perry, Christopher G.R.; Kane, Daniel A.; Lanza, Ian R.; Neufer, P. Darrell (2013-03-14)
    A growing body of research is investigating the potential contribution of mitochondrial function to the etiology of type 2 diabetes. Numerous in vitro, in situ, and in vivo methodologies are available to examine various ...

  • Methods for Assessing Mitochondrial Function in Diabetes 

    Perry, Christopher G.R.; Kane, Daniel A.; Lanza, Ian R.; Neufer, P. Darrell (2013-04)
    A growing body of research is investigating the potential contribution of mitochondrial function to the etiology of type 2 diabetes. Numerous in vitro, in situ, and in vivo methodologies are available to examine various ...

  • Mitochondrial H₂O₂ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans 

    Anderson, Ethan; Lustig, Mary E.; Boyle, Kristen E.; Woodlief, Tracey L.; Kane, Daniel A.; Lin, Chien-Te; Price, Jesse W. III; Kang, Li; Rabinovitch, Peter S.; Szeto, Hazel H.; Houmard, Joseph A.; Cortright, Ronald N.; Wasserman, David H.; Neufer, P. Darrell (2009-03)
    High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidative stress have been ...