Browsing by Author "Kang, Li"
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Diet-Induced Muscle Insulin Resistance Is Associated With Extracellular Matrix Remodeling and Interaction With Integrin αβ in Mice
Kang, Li; Ayala, Julio E.; Lee-Young, Robert S.; Zhang, Zhonghua; James, Freyja D.; Neufer, P. Darrell; Pozzi, Ambra; Zutter, Mary M.; Wasserman, David H. (2011-02) -
Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin α<inf>2</inf>β <inf>1</inf>in mice
Kang, Li; Ayala, Julio E.; Lee-Young, Robert S.; Zhang, Zhonghua; James, Freyja D.; Neufer, P. Darrell; Pozzi, Ambra; Zutter, Mary M.; Wasserman, David H. (2011)OBJECTIVE: The hypothesis that high-fat (HF) feeding causes skeletal muscle extracellular matrix (ECM) remodeling in C57BL/6J mice and that this remodeling contributes to diet-induced muscle insulin resistance (IR) through ... -
Enhanced Mitochondrial Superoxide Scavenging Does Not Improve Muscle Insulin Action in the High Fat-Fed Mouse
Lark, Daniel Stephen; Kang, Li; Lustig, Mary E.; Bonner, Jeffrey S.; James, Freyja D.; Neufer, P. Darrell; Wasserman, David H. (2015-05)Improving mitochondrial oxidant scavenging may be a viable strategy for the treatment of insulin resistance and diabetes. Mice overexpressing the mitochondrial matrix isoform of superoxide dismutase (sod2tg mice) and/or ... -
Enhanced Mitochondrial Superoxide Scavenging Does Not Improve Muscle Insulin Action in the High Fat-Fed Mouse
Lark, Daniel S.; Kang, Li; Lustig, Mary E.; Bonner, Jeffrey S.; James, Freyja D.; Neufer, Darrell; Wasserman, David H. (2015-05)Improving mitochondrial oxidant scavenging may be a viable strategy for the treatment of insulin resistance and diabetes. Mice overexpressing the mitochondrial matrix isoform of superoxide dismutase (sod2tg mice) and/or ... -
Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but Not Insulin Action, in High-Fat–Fed Mice
Kang, Li; Dai, Chunhua; Lustig, Mary E.; Bonner, Jeffrey S.; Mayes, Wesley H.; Mokshagundam, Shilpa; James, Freyja D.; Thompson, Courtney S.; Lin, Chien-Te; Perry, Christopher G.R.; Anderson, Ethan; Neufer, P. Darrell; Wasserman, David H.; Powers, Alvin C. (2014-11) -
Mitochondrial H₂O₂ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
Anderson, Ethan; Lustig, Mary E.; Boyle, Kristen E.; Woodlief, Tracey L.; Kane, Daniel A.; Lin, Chien-Te; Price, Jesse W. III; Kang, Li; Rabinovitch, Peter S.; Szeto, Hazel H.; Houmard, Joseph A.; Cortright, Ronald N.; Wasserman, David H.; Neufer, P. Darrell (2009-03)High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidative stress have been ...