Browsing by Author "Leontovich, Alexey A."

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  • Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells 

    Leontovich, Alexey A.; Salisbury, Jeffrey L.; Veroux, Massimiliano; Tallarita, Tiziano; Billadeau, Daniel; McCubrey, James A.; Ingle, James N.; Galanis, Evanthia; D'Assoro, Antonino B. (2013-05)
    Centrosome amplification plays a key role in the origin of chromosomal instability (CIN) during cancer development and progression. In this study, MCF-7 breast cancer cell lines harboring abrogated p53 function (vMCF-7DNp53) ...

  • NOTCH3 Expression Is Linked to Breast Cancer Seeding and Distant Metastasis 

    Leontovich, Alexey A.; Jalalirad, Mohammad; Salisbury, Jeffrey L.; Mills, Lisa; Haddox, Candace; Schroeder, Mark; Tuma, Ann; Guicciardi, Maria E.; Zammataro, Luca; Gambino, Mario W.; Amato, Angela; Di Leonardo, Aldo; McCubrey, James; Lange, Carol A.; Liu, Minetta; Haddad, Tufia; Goetz, Matthew; Boughey, Judy C.; Sarkaria, Jann; Wang, Liewei; Ingle, James N.; Galanis, Evanthia; D’Assoro, Antonino B. (2018-09-04)
    Background: Development of distant metastases involves a complex multistep biological process termed the invasion-metastasis cascade, which includes dissemination of cancer cells from the primary tumor to secondary organs. ...