Browsing by Author "Lim, Kwang Hun"
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Elucidating the Mechanisms of Transthyretin Aggregation in Transthyretin Amyloidosis
Dasari, Anvesh K. R. (East Carolina University, 2018-07-24)Accumulation of insoluble aggregates (amyloids) is a characteristic feature of many neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Aggregation and deposition of Transthyretin (TTR) protein ... -
Investigation of Molecular Mechanism of Transthyretin Oligomerization Associated with ATTR Amyloidosis
Coats, Matthew Fontaine (East Carolina University, 2022-04-27)Transthyretin amyloidosis (ATTR) has classically been diagnosed predominantly post-observation of amyloid fibril deposition on soft tissues within the body, however, recent studies have shown that oligomers which arise ... -
NMR characterizations of an amyloidogenic conformational ensemble of the PI3K SH3 domain
Ahn, Hee-Chul; Le, Yen T. H.; Nagchowdhuri, Partha S.; Derose, Eugene F.; Putnam-Evans, Cindy; London, Robert E.; Markley, John L.; Lim, Kwang Hun (East Carolina University, 2006-11)Amyloid formation is associated with structural changes of native polypeptides to monomeric intermediate states and their self-assembly into insoluble aggregates. Characterizations of the amyloidogenic intermediate state ... -
Tau Induces Formation of α-synuclein Filaments with Distinct Molecular Conformations
Dasari, Anvesh K. R.; Lim, Kwang Hun; Hojjatian, Alimohammad; Sengupta, Urmi; Taylor, Dianne; Daneshparvar, Nadia; Yeganeh, Fatemeh Abbasi; Dillard, Lucas; Michael, Brian; Griffin, Robert G.; Borgnia, Mario; Kayed, Rakez; Taylor, Kenneth A. (2021) -
Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers
Dasari, Anvesh K. R.; Hughes, Robert M.; Wi, Sungsool; Hung, Ivan; Gan, Zhehong; Kelly, Jeffrey W.; Lim, Kwang Hun (2019-01-10)Characterization of small oligomers formed at an early stage of amyloid formation is critical to understanding molecular mechanism of pathogenic aggregation process. Here we identifed and characterized cytotoxic oligomeric ... -
Transthyretin Amyloidosis: Proteolytic cleavage accelerates G53A TTR misfolding and aggregation
Arreola, Jenette (East Carolina University, 2020-06-22)The proteolytic cleavage of the peptide bond Lys48-Thr49 of the CD loop in TTR pathological mutants S52P and E51_S52dup was previously demonstrated to promote aggregation as a result of tetrameric structure destabilization. ...