Browsing by Author "Litwa, Karen"
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Adamts9 is critical for the development of primary ovarian follicles
Carver, Jonathan Jacob (East Carolina University, 2022-07-19)Adamts9 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 9) is an extracellular matrix metalloprotease that is highly evolutionarily conserved and critical for development in vertebrates. ... -
The Applicability of Current Turbidimetric Approaches for Analyzing Fibrin Fibers and Other Filamentous Networks
Belcher, Heather A.; Hudson, Nathan E.; Litwa, Karen; Guthold, Martin (2022-06-09) -
CB1 Antagonism Increases Excitatory Synaptogenesis in a Cortical Spheroid Model of Fetal Brain Development
Papariello, Alexis; Taylor, David; Soderstrom, Ken; Litwa, Karen (2021) -
Colocalization of Known Focal Adhesion Proteins and Novel Focal Adhesion Protein GPR98 in Human Neurites during Neuronal Development in 2 and 3 Dimensions
Petritsch, Amanda (East Carolina University, 2022-07-29)Focal adhesions are critical to cell motility, morphology, and neuronal circuit formation. Proper neuronal circuit formation relies on neurons reaching the right location, assuming a specific morphology, and connecting ... -
Colocalization of Known Focal Adhesion Proteins and Novel Focal Adhesion Protein GPR98 in Human Neurites during Neuronal Development in 2 and 3 Dimensions
Petritsch, Amanda Michelle (East Carolina University, 2022-07-29)Focal adhesions are critical to cell motility, morphology, and neuronal circuit formation. Proper neuronal circuit formation relies on neurons reaching the right location, assuming a specific morphology, and connecting ... -
Diseased: An Artistic Depiction of Public Health Issues and Their Causes
Robbins, Marian (East Carolina University, 2020-05-04)Public health is a form of healthcare that aims to improve the health of communities through preventative methods. This includes law-making, public education, and control of the spread of disease. By using detailed imagery ... -
Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Developing Neural Circuits in a Model of the Human Fetal Cortex
Tate, Kinsley; Kirk, Brenna; Tseng, Alisia; Ulffers, Abigail; Litwa, Karen (2021-09-28) -
Pharmacological Regulation of Neural Circuit Formation in hIPSC-Derived Neurons and ‘Mini-Brains’
Rudisill, Taylor Lee (East Carolina University, 2018-07-20)Emerging evidence suggests that altered neural connectivity, particularly at the level of synaptic connections, contributes to the pathology of many neurodevelopmental and neurodegenerative diseases. For instance, post-mortem ... -
Role of antidepressants in fetal synapse formation in Autism Spectrum Disorders
Tate, Kinsley M (East Carolina University, 2018-07-23)Autism is a genetically complex neurodevelopmental disorder in which patients exhibit social deficits in both verbal and non-verbal forms of communication and display restricted and repetitive behaviors. Approximately 1 ... -
Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development
Wilson, Emily S.; Litwa, Karen (2021-09-28) -
Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development
Wilson, Emily S.; Litwa, Karen (MDPI, 2021-09-28)The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons. Since perineuronal nets form postnatally, ... -
The Endocannabinoid System Regulates Synaptogenesis in a Cortical Spheroid Model of Fetal Neurodevelopment
Papariello, Alexis (East Carolina University, 2021-07-20)The endocannabinoid system plays a complex role in synaptogenesis and the subsequent development of neural circuitry during fetal brain development. The cannabinoid receptor type 1 controls synaptic strength at both ... -
THE HYALURONAN EXTRACELLULAR MATRIX CRITICALLY REGULATES SYNAPSE FORMATION IN DEVELOPING NEURAL NETWORKS
Wilson, Emily S (East Carolina University, 2021-04-21)The majority of neurodevelopmental disorders present with an imbalance in synaptic signal transmission. The delicate balance of excitatory to inhibitory synaptic transmission is regulated by multiple extracellular and ... -
TIMECOURSE OF SYNAPSE DEVELOPMENT IN HUMAN IPSC-DERIVED NEURONS
Orbita, Adrienne Marie (East Carolina University, 2019-06-12)Understanding the underlying mechanisms in brain formation give an insight to what affects the formation of the brain when affected with autism, specifically, the excitatory and inhibitory synapses. The mechanism of how ...