Browsing by Author "Matsubara, Tomoko"
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Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment
Cao, Yang; Matsubara, Tomoko; Zhao, Can; Gao, Wei; Peng, Linxiu; Shan, Jinjun; Liu, Zhengxia; Yuan, Fang; Tang, Lingyi; Li, Peixin; Guan, Zhibin; Fang, Zhuyuan; Lu, Xiang; Huang, Hu; Yang, Qin (2017-08-24)Using the principle of antibody-drug conjugates that deliver highly potent cytotoxic agents to cancer cells for cancer therapy, we here report the synthesis of antisense-oligonucleotides (ASO) and thyroid hormone T3 ... -
The effects of exercise on hypothalamic neurodegeneration of Alzheimer’s disease mouse model
Do, Khoa; Laing, Brenton Thomas; Landry, Taylor; Bunner, Wyatt; Mersaud, Naderi; Matsubara, Tomoko; Li, Peixin; Yuan, Yuan; Lu, Qun; Huang, Hu (2018-01-02)Alzheimer’s disease is a neurodegenerative disorder that affects the central nervous sys- tem. In this study, we characterized and examined the early metabolic changes in the triple transgenic mouse AD model (3xtg-AD), and ...