Browsing by Author "McCubrey, JA"
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Characterization of proteins binding the 3′ regulatory region of the IL-3 gene in IL-3-dependent and autocrine-transformed hematopoietic cells
Wang, X-Y; Hoyle, PE; McCubrey, JA (1998-03-08)Previously we documented the prolongation of the IL-3 mRNA half-life in an autocrine-transformed cell line. This cell line has an intracisternal type A particle transposition in the IL-3 mRNA 3′ untranslated region which ... -
Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells
Blalock, WL; Moye, PW; Chang, Fumin; Pearce, M; LS, Steelman; McMahon, M; McCubrey, JA (2000-06-06)The MEK1 oncoprotein plays a critical role in Ras/Raf/ MEK/MAPK-mediated transmission of mitogenic signals from cell surface receptors to the nucleus. In order to examine this pathway's role in leukemic transformation, a ... -
Therapeutic targeting of CK2 in acute and chronic leukemias
Buontempo, Francesca; McCubrey, JA; Orsini, E; Ruzzene, M; Cappellini, Alessandra; Lonetti, A; Evangelisti, Camilla; Chiarini, Francesca; Evangelisti, C; Barata, JT; Martelli, AM (2018-01)Phosphorylation can regulate almost every property of a protein and is involved in all fundamental cellular processes. Thus, proper regulation of phosphorylation events is critical to the homeostatic functions of cell ...