Browsing by Author "Neri, Luca M."
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Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation
Simioni, Carolina; Cani, Alice; Martelli, Alberto M.; Zauli, Giorgio; Tabellini, Giovanna; McCubrey, James A.; Capitani, Silvano; Neri, Luca M. (2014-10)The PI3K/Akt/mTOR signaling cascade is a key regulatory pathway controlling cell growth and survival, and its dysregulation is a reported feature of B-precursor acute lymphoblastic leukemia (B-pre ALL). Torin-2 is a ... -
The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy
Simioni, Carolina; Martelli, Alberto M.; Cani, Alice; Cetin-Atalay, Rengul; McCubrey, James A.; Capitani, Silvano; Neri, Luca M. (2013-09)Hepatocellular carcinoma (HCC) is one of the most common potentially lethal human malignancies worldwide. Advanced or recurrent HCC is frequently resistant to conventional chemotherapeutic agents and radiation. Therefore, ... -
The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy
Simioni, Carolina; Martelli, Alberto M.; Cani, Alice; Cetin-Atalay, Rengul; McCubrey, James A.; Capitani, Silvano; Neri, Luca M. (2013-08-24)Hepatocellular carcinoma (HCC) is one of the most common potentially lethal human malignancies worldwide. Advanced or recurrent HCC is frequently resistant to conventional chemotherapeutic agents and radiation. Therefore, ... -
Cardiovascular disease-related miRNAs expression: potential role as biomarkers and effects of training exercise
Ultimo, Simona; Zauli, Giorgio; Martelli, Alberto M.; Vitale, Marco; McCubrey, James A.; Capitani, Silvano; Neri, Luca M. (2018-03-30)Cardiovascular diseases (CVDs) are one of the most important causes of mortality worldwide, therefore the need of effective preventive strategies is imperative. Aging is associated with significant changes in both ... -
Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression
Steelman, Linda S.; Abrams, Stephen L.; Ruvolo, Peter; Ruvolo, Vivian; Cocco, Lucio; Ratti, Stefano; Martelli, Alberto M.; Neri, Luca M.; Candido, Saverio; Libra, Massimo; McCubrey, James A. (2017-12-06)Chemotherapeutic drug treatment can result in the emergence of drug-resistant cells. By culturing an interleukin-3 (IL-3)-dependent cell line, FL5.12 cells in the presence of the chemotherapeutic drug doxorubicin, we ... -
The novel dual PI3K/mTOR inhibitor NVP-BGT226 displays cytotoxic activity in both normoxic and hypoxic hepatocarcinoma cells
Simioni, Carolina; Cani, Alice; Martelli, Alberto M.; Zauli, Giorgio; Alameen, Ayman A.M.; Ultimo, Simona; Tabellini, Giovanna; McCubrey, James A.; Capitani, Silvano; Neri, Luca M. (2015-07)Hepatocellular carcinoma (HCC) is one of the most common lethal human malignancies worldwide and its advanced status is frequently resistant to conventional chemotherapeutic agents and radiation. We evaluated the cytotoxic ... -
PI3K isoform inhibition associated with anti Bcr-Abl drugs shows in vitro increased anti-leukemic activity in Philadelphia chromosome-positive B-acute lymphoblastic leukemia cell lines
Ultimo, Simona; Simioni, Carolina; Martelli, Alberto M.; Zauli, Giorgio; Evangelisti, Camilla; Celeghini, Claudio; McCubrey, James A.; Marisi, Giorgia; Ulivi, Paola; Capitani, Silvano; Neri, Luca M. (2017-02-20)B-acute lymphoblastic leukemia (B-ALL) is a malignant disorder characterized by the abnormal proliferation of B-cell progenitors. Philadelphia chromosome-positive (Ph+) B-ALL is a subtype that expresses the Bcr-Abl fusion ... -
Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells
McCubrey, James A.; Fitzgerald, Timothy L.; Yang, Li V.; Lertpiriyapong, Kvin; Steelman, Linda S.; Abrams, Stephen L.; Montalto, Giuseppe; Cervello, Melchiorre; Neri, Luca M.; Cocco, Lucio; Martelli, Alberto M.; Laidler, Piotr; Dulińska-Litewka, Joanna; Rakus, Dariusz; Gizak, Agnieszka; Nicoletti, Ferdinando; Falzone, Luca; Candido, Saverio; Libra, Massimo (2017-02)Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/ Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 ... -
Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia
Cani, Alice; Simioni, Carolina; Martelli, Alberto M.; Zauli, Giorgio; Tabellini, Giovanna; Ultimo, Simona; McCubrey, James A.; Capitani, Silvano; Neri, Luca M. (2015-03)T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive neoplastic disorder in which chemotherapy resistance and refractory relapses occur, with a poorer prognostic outcome. Constitutively active PI3K/Akt/mTOR ...