Browsing by Author "Offenbacher, Adam"
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ELUCIDATION OF 15-LIPOXYGENASE-2 AND PEBP1 INTERACTIONS IMPLICATED IN ACUTE RENAL FAILURE
Ray, Katherine (East Carolina University, 2019-05-14)15-Lipoxygenase-2 (15-LOX-2) is one of six human lipoxygenase enzymes that catalyze the peroxidation of fatty acids and are involved in many different cell signaling pathways related to development, homeostasis, and even ... -
Elucidation of allosteric behavior and enzyme-effector complexes of human 15-lipoxygenase-2 through hydrogen-detuerium exchange mass spectrometry
Musgrave, Amy (East Carolina University, 2019-05-03)The enzymatic activity of human 15-lipoxygenase-2 (15-LOX-2) has been implicated in human inflammatory diseases such as atherosclerotic cardiovascular disease and plays an important role in maintaining homeostasis. 15-LOX-2 ... -
Investigating the Structural and Functional Roles of Conserved Cysteine Residues in Arabidopsis thaliana Fatty-Acid Desaturase 2
Novotny, Lauren (East Carolina University, 2022-12-06)Plant-generated unsaturated fatty acids (UFAs) and polyunsaturated fatty acids (PUFAs) are vital to a plant’s growth and survival through maintenance of plasma membrane fluidity and integrity, in addition to the various ... -
Investigation of NADPH-Dependent Thioredoxin Reductase-C (NTRC) In Chloroplast Lipid Metabolism
Donnelly, Shannon (East Carolina University, 2022-07-01)Redox reactions are ubiquitous within plant metabolism and critical for the sustainment of photosynthesis within thylakoid membranes. Specialized glycerolipids that make up these membranes in turn require redox reactions ... -
The Role of Tryptophan and Its Derivatives in Elucidating A PCET Mechanism in the Model Protein Azurin
Long, Hanna LK (East Carolina University, 2021-04-23)The role and properties of electron-rich tyrosine in the proton-coupled electron transport (PCET) pathway has been extensively studied, specifically relating to ribonucleotide reductase. Tryptophan is another electron-rich ...