Browsing by Subject "Amino acids"
Now showing items 1-4 of 4
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Electrochemical Detection of Anti-Biofilm Activity Using Unnatural Amino Acid-Containing Antimicrobial Peptides
(East Carolina University, 2015)Bacterial infections are a significant health problem that can be detrimental to the human population. It is estimated that bacterial infections are responsible for billions of dollars’ worth of damages in the health care ... -
Elucidating the Mechanism of Action of Unnatural Amino Acid Containing Antimicrobial Peptides in Membrane Environments
(East Carolina University, 2012)Organism resistance continues to develop to the currently available antimicrobial compounds necessitating the development of innovative new therapeutic compounds with different specificities and mechanisms of action that ... -
Installation of Metal-Binding Functionality at Lysine Residues via Azide-Alkyne "Click Chemistry"
(2015-04-29)A novel non-natural amino acid designed to bind divalent metal ions, dubbed Lys(PYRIT), was prepared in a “click reaction” by treating Fmoc-Lys(N3)-OH with 2-ethynylpyridine and Cu(I). It was incorporated into a 12-residue ... -
Investigating the Interaction of RecQL4 and Mcm10 in Drosophila melanogaster
(East Carolina University, 2014)Accurate duplication and regulation of the eukaryotic genome requires precise coordination among multiple replication factors. RecQL4, the least characterized RecQ protein, is a 1208 amino acid protein containing a centrally ...