Browsing by Subject "Hyaluronic Acid"
Now showing items 1-4 of 4
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A QUEST FOR ARTICULAR CARTILAGE PROGENITOR CELLS LEADS TO TEMPORAL REGULATION OF HYALURONAN REQUIRED FOR 3T3-L1 ADIPOGENESIS
(East Carolina University, 2017-07-13)During embryogenesis, mesenchymal progenitor cells exhibit hyaluronan-dependent pericellular matrices as a major component of the extracellular matrix. As connective tissues form by cellular condensations, there is a loss ... -
CD44 and hyaluronan promote the bmp7 signaling response in chondrocytes
(East Carolina University, 2011)Cell-matrix interactions are important in maintaining cartilage homeostasis. Hyaluronan binding to its principal receptor CD44 is essential for such interactions. Hyaluronan-CD44 interactions are required for the retention ... -
CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention
(East Carolina University, 2016-12-15)Hyaluronan (HA) plays an essential role in cartilage where it functions to retain aggrecan. Previous studies suggested that aggrecan is anchored indirectly to the plasma membrane of chondrocytes via its binding to ... -
THE HYALURONAN EXTRACELLULAR MATRIX CRITICALLY REGULATES SYNAPSE FORMATION IN DEVELOPING NEURAL NETWORKS
(East Carolina University, 2021-04-21)The majority of neurodevelopmental disorders present with an imbalance in synaptic signal transmission. The delicate balance of excitatory to inhibitory synaptic transmission is regulated by multiple extracellular and ...