Browsing by Subject "Nervous system--Degeneration"
Now showing items 1-3 of 3
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Investigation of Nonhydrolyzable ATP Analogues and Cofilin-Derived Peptides for Inhibition of Cofilin-Actin Rod Formation
(East Carolina University, 2021-08-02)Actin-Cofilin rods are an important marker of neurodegenerative disease and are commonly observed in the neurons of patients with Alzheimer's disease. The goal of this research is to investigate peptide and small-molecules ... -
Thermodynamic Investigations into Copper Binding in the N-Terminal Region of the Prion Protein at Low Copper Loadings
(East Carolina University, 2010)The prion protein (PrP) is a naturally occurring protein found at high levels in central nervous system (CNS). The misfolding of the PrP is responsible for neurodegenerative diseases called transmissible spongioform ... -
Toxic Effects of Chlorpyrifos Exposure on Development of Caenorhabditits Elegans
(East Carolina University, 2016-12-15)Chlorpyrifos is a commonly utilized organophosphate pesticide, and as recently as 2007, was the most commonly used insecticide within the United States. Its ubiquity is concerning given its potential to cause developmental ...