Browsing by Subject "breast cancer"
Now showing items 1-12 of 12
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A SECONDARY DATA ANALYSIS ON THE RELATIONSHIP BETWEEN BREAST CANCER SURVIVORS’ SYMPTOMS AND PHYSICAL ACTIVITY LEVELS MEASURED BY FITBIT (STEPS/DAY)
(East Carolina University, 2020-05-04)Survival rates for breast cancer have increased significantly in recent years. Although more patients are surviving now, these women still experience many symptom clusters years post-treatment. One such cluster includes ... -
Exploring Interactive Survivorship Care Plans to Support Breast Cancer Survivors: Protocol for a Randomized Controlled Trial
(2020-12-04)Background: Breast cancer is the most common form of cancer among American women, accounting for 23% of all cancer survivors nationally. Yet, the availability of adequate resources and tools for supporting breast cancer ... -
Identification of galectin-1 as a marker for claudin-low breast cancer and implications for tumor progression
(East Carolina University, 2024-01-04)Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Patients with TNBC have a high rate of metastasis and mortality due to the lack of targeted therapies and resistance to chemotherapy. This ... -
Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells
(2013-05)Centrosome amplification plays a key role in the origin of chromosomal instability (CIN) during cancer development and progression. In this study, MCF-7 breast cancer cell lines harboring abrogated p53 function (vMCF-7DNp53) ... -
Inhibition of Cdk2 kinase activity selectively targets the CD44/CD24 stem-like subpopulation and restores chemosensitivity of SUM149PT triple-negative breast cancer cells
(2014-09)Inflammatory breast cancer (IBC) is an angioinvasive and most aggressive type of advanced breast cancer characterized by rapid proliferation, chemoresistance, early metastatic development and poor prognosis. IBC tumors ... -
m6A Regulates Breast Cancer Proliferation and Migration through Stage-dependent Changes in Epithelial to Mesenchymal Transition Gene Expression
(2023-11-07)While many factors have been implicated in breast cancer progression, effective treatments are still lacking. In recent years, it has become clear that posttranscriptional regulation plays a key role in the aberrant gene ... -
N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression
(2018-07-27)The mRNA modification N6-methyladenosine (m6A) is involved in many post-transcriptional regulatory processes including mRNA stability and translational efficiency. However, it is also imperative to correlate these processes ... -
Search Strategy for Effects of Adjuvant Endocrine Treatment on Cognition and Language in Women with Breast Cancer
(2020-06-18)This is the full set of search strategies for a systematic review examining effects of adjuvant endocrine therapies concerning language and cognitive functioning in women with breast cancer. Databases searched include: ... -
THE ROLE OF N6-METHYLADENOSINE IN HYPOXIA AND CELLULAR TRANSFORMATION
(East Carolina University, 2017-11-29)Cancer is a prevalent disease that affects millions of people each year across the globe. In an effort to find therapies to the many types of cancers, regulation of protein expression through transcription and translation ... -
Understanding the Experience and Management of Musculoskeletal Symptoms in Breast Cancer Survivors on Aromatase Inhibitor Therapy
(East Carolina University, 2018-05-03)PURPOSE/OBJECTIVES: To explore the perception of women currently receiving or who have received adjuvant AI therapy of the side effects (specifically MSK symptoms) and their methods of managing these symptoms RESEARCH ...