Browsing by Subject "cancer"
Now showing items 1-20 of 24
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Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
(2013-10)The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection ... -
Animal Viruses, Bacteria, and Cancer: A Brief Commentary
(2014-02)Animal viruses and bacteria are ubiquitous in the environment. However, little is known about their mode of transmission and etiologic role in human cancers, especially among high-risk groups (e.g., farmers, veterinarians, ... -
Apoptosis mechanisms induced by 15d-PMJ2 in HCT116 colon cancer cells: insights into CHOP10/TRB3/Akt signaling
(2023-11-02)Agents that stimulate the endoplasmic reticulum (ER) stress pathway are being exploited pharmacologically to induce cancer cell death. Cytotoxic ER stress is typically regulated by the transcription factor, C/EBP homologous ... -
Comparison of Mitochondrial Phenotypes Across Cancers with Different Tissues of Origin
(East Carolina University, 2021-12-06)Cancer metabolism is typically characterized by aerobic glycolysis, an increase in glucose uptake and lactate production despite adequate sufficient oxygen availability to support mitochondrial oxidative phosphorylation ... -
Electrochemical Detection of DNA Methylation and Implications for Detection of Cancer Onset Resulting from Hypermethylation
(East Carolina University, 2017-05-05)Epigenetics refers to the process by which genetic material is modified without changing the base coding sequence1. One such epigenetic process is DNA methylation, employed by cells to regulate gene expression, often by ... -
Exploring Alternative Strategies for the Synthesis of 15d-PGJ2-EA: Diversification of Synthetic Routes to a Potent Anti-Cancer Agent
(East Carolina University, 2016-04-29)The compound, 15-deoxy-12, 14-prostaglandin-J2-ethanolamine (15d-PGJ2-EA), is in an active line of research for treating non-melanoma skin cancer and has shown promising potential as a chemotherapeutic drug. 15d-PGJ2-EA ... -
Hox-gene expression as a biomarker for igf-1r therapeutics
(2008-09-25)This invention provides methods for treating or preventing the onset of a tumor in a subject, wherein the tumor is determined to overexpress a Hox gene, including administering to the subject a therapeutically or ... -
HUMAN RNA METHYLTRANSFERASE METTL16 AFFECTS MULTIPLE CELL PROCESSES THROUGH DIFFERENTIAL FUNCTION OF ITS DOMAINS
(East Carolina University, 2022-11-10)ABSTRACT In recent years, disease therapies have been developed to target specific RNA and protein expression changes in the affected cells/tissue. The RNA post-transcriptional modification, methyl-6-adenosine (m6A), has ... -
MCM10 Genetic Screen Using Drosophila melanogaster
(East Carolina University, 2016-04-28)Genes and the proteins they encode are responsible for virtually every aspect of life. The vast array of biological processes make it difficult to identify genes to study that are relevant to human diseases. MCM10 (short ... -
Method of detecting cancer using delta-catenin
(2008-11-04)The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from ... -
PERSPECTIVES OF PAIN, SPIRITUALITY, AND ADVANCE CARE PLANNING AMONG LATINO ADULTS WITH CANCER
(East Carolina University, 2023-04-26)Latinos are the largest minority group in the United States and experience inequality in their receipt of palliative care resources and services. This descriptive study examines the connection between pain, spirituality, ... -
Recent discoveries in the cycling, growing and aging of the p53 field
(2012-12)The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. ... -
Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes
(2012-12)It is widely believed that aging results from the accumulation of molecular damage, including damage of DNA and mitochondria and accumulation of molecular garbage both inside and outside of the cell. Recently, this paradigm ... -
Recent progress in targeting cancer
(2011-12)In recent years, numerous new targets have been identified and new experimental therapeutics have been developed. Importantly, existing non-cancer drugs found novel use in cancer therapy. And even more importantly, new ... -
Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer
(2014-03)Cancer remains one of the major cause of death in the Western world. Although, it has been demonstrated that new therapies can improve the outcome of cancer patients, still many patients relapse after treatment. Therefore, ...