Now showing items 1-4 of 4

  • Expression of microRNA in Alveolar Macrophages Deficient in PPARy 

    McPeek, Matthew (East Carolina University, 2014)
    The nuclear transcription factor Peroxisome proliferator-activated receptor gamma (PPARgamma) is a negative regulator of macrophage activation and inflammatory mediators. Alveolar macrophages of healthy individuals ...
  • Gene-environment interactions in sarcoidosis 

    Culver, Daniel A.; Newman, Lee S.; Kavuru, Mani S. (East Carolina University, 2007-05)
    Susceptibility to most human diseases is polygenic, with complex interactions between functional polymorphisms of single genes governing disease incidence, phenotype, or both. In this context, the contribution of any ...
  • Review: Carbon Nanotubes and Chronic Granulomatous Disease 

    Barna, Barbara P.; Judson, Marc A.; Thomassen, Mary Jane (2014-06-23)
    Use of nanomaterials in manufactured consumer products is a rapidly expanding industry and potential toxicities are just beginning to be explored. Combustion-generated multiwall carbon nanotubes (MWCNT) or nanoparticles ...
  • Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells 

    Gharib, Sina A.; Malur, Anagha; Huizar, Isham; Barna, Barbara P.; Kavuru, Mani S.; Schnapp, Lynn M.; Thomassen, Mary J. (2016-07-26)
    Abstract Background Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased ...