Browsing Physiology by Author "Durante, William"
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Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries
Peyton, Kelly J.; Ensenat, Diana; Azam, Mohammad A.; Keswani, Amit N.; Kannan, Sankaranarayanan; Liu, Xiao-Ming; Wang, Hong; Tulis, David A.; Durante, William (East Carolina University, 2009-04)Objective—Arginase stimulates the proliferation of cultured vascular smooth muscle cells (VSMCs); however, the influence of arginase on VSMC growth in vivo is not known. This study investigated the impact of arginase on ... -
The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through anti-proliferative and pro-apoptotic effects
Keswani, Amit N.; Peyton, Kelly J.; Durante, William; Schafer, Andrew I.; Tulis, David A. (East Carolina University, 2009-06)Guanosine-specific cyclic nucleotide signaling is suggested to serve protective actions in the vasculature; however, the influence of selective pharmacologic modulation of cyclic guanosine monophosphate (GMP)-synthesizing ... -
YC-1 Stimulates the Expression of Gaseous Monoxide-Generating Enzymes in Vascular Smooth Muscle Cells
Liu, Xiao-Ming; Peyton, Kelly J.; Mendelev, Natalia N.; Wang, Hong; Tulis, David A.; Durante, William (East Carolina University, 2009-01)The benzylindazole derivative 3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole (YC-1) is an allosteric stimulator of soluble guanylate cyclase (sGC) that sensitizes the enzyme to the gaseous ligands carbon monoxide (CO) and ...