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IMPACT OF INTRINSIC AEROBIC EXERCISE CAPACITY ON CARDIOVASCULAR OUTCOMES FOLLOWING VARIOUS FORMS OF CARDIOVASCULAR STRESS
(East Carolina University, 2020-06-22)
Cardiovascular diseases (CVD) remain the major leading cause of death in the western world. Therefore, several approaches to achieve cardioprotection against any cardiovascular insult have been explored and to date, the ...
MECHANISMS OF LEFT VENTRICULAR REMODELING IN PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS
(East Carolina University, 8/5/2020)
Cardiac remodeling is composed of molecular, cellular, and interstitial changes in the cardiac tissue that affect the size, shape, and function of the heart. There are two types of cardiac remodeling: physiological and ...
Apparatus and method for measuring physiological characteristics of an intact trachea in vitro
(2011-03-15)
Apparatus and methods for measuring smooth muscles responses (relaxation and contraction), transepithelial potential difference, and/or transepithelial impedance of an intact trachea in vitro. In particular embodiments, ...
Neurovascular Mechanisms of Erectile Dysfunction Following Androgen Deprivation Therapy
(East Carolina University, 2019-12-20)
For nearly eight decades, androgen deprivation therapy (ADT) has been a common prostate cancer treatment. Although ADT increases the prostate cancer survival rate, urogenital side effects such as erectile dysfunction (ED) ...
Comparison of Mitochondrial Phenotypes Across Cancers with Different Tissues of Origin
(East Carolina University, 2021-12-06)
Cancer metabolism is typically characterized by aerobic glycolysis, an increase in glucose uptake and lactate production despite adequate sufficient oxygen availability to support mitochondrial oxidative phosphorylation ...
Deciphering the impact of fructose metabolism on liver mitochondrial bioenergetics
(East Carolina University, 2021-12-07)
Since its discovery in 1980, the interest in nonalcoholic fatty liver disease, the liver manifestation of metabolic syndrome, has expanded due to the growing impact on the world's health. Commonly characterized by ...